The relationship between depression and physical symptom burden in advanced cancer
The relationship between depression and physical symptom burden in advanced cancer
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DOI：
10.1136/bmjspcare-2012-000380
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发表时间：
2015-12-01
影响因子：
2.7
通讯作者：
Rodin, Gary
中科院分区：
文献类型：
--
作者：
Fitzgerald, Peter;Lo, Chris;Rodin, Gary
背景：虽然抑郁症与身体负担之间的关系已在晚期癌症中得到证实，但目前尚不清楚这种联系在多大程度上仅限于特定的身体症状，如疼痛和疲劳，并受疾病和治疗相关因素的影响。因此，我们调查了该人群中多种身体症状的抑郁和身体负担之间的关系，同时控制了癌症相关因素，包括疾病严重程度和接近死亡。患者和方法对487名晚期癌症患者的横断面数据进行二次分析。衡量标准包括贝克抑郁问卷II和纪念症状评估量表，该量表测量了24种常见癌症症状的身体负担。结果抑郁症严重程度与躯体症状数、症状苦恼及症状严重程度显著相关，与癌症类型、功能状态、化疗状态及生存期无关(P均<0.05)。
Background Although an association between depression and physical burden has been demonstrated in advanced cancer, it remains unclear to what extent this is limited to specific physical symptoms, such as pain and fatigue, and is mediated by disease and treatment-related factors. We therefore investigated the relationship between depression and physical burden across a multitude of physical symptoms in this population, while controlling for cancer-related factors including disease severity and proximity to death.Patients and methods A secondary analysis was performed on cross-sectional data in 487 patients with advanced cancer. Measures included the Beck Depression Inventory II and the Memorial Symptom Assessment Scale, which measured physical burden across 24 common cancer symptoms. Disease severity was assessed by survival time and by functional status using the Karnofsky Performance Status scale.Results Depression severity significantly correlated with number of physical symptoms, symptom distress and symptom severity independent of cancer type, functional status, chemotherapy status and survival time (all p