DOSE-RESPONSE RELATIONSHIPS IN THE THERMOREGULATORY EFFECTS OF CAPSAICIN
DOSE-RESPONSE RELATIONSHIPS IN THE THERMOREGULATORY EFFECTS OF CAPSAICIN
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DOI：
10.1007/bf00506307
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发表时间：
1982-01-01
影响因子：
3.6
通讯作者：
OBAL, F
中科院分区：
文献类型：
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作者：
SZIKSZAY, M;OBAL, F;OBAL, F
在大鼠中研究了辣椒素的低温效应、对药物的低温效应的降低的反应性以及在给予不同剂量的辣椒素之后在温暖环境中体温调节的损害。1.皮下注射1-10 mg/kg辣椒素可引起体温下降，并呈剂量依赖性，持续2-5 h。10 mg/kg的单次剂量引起最明显的低温效应，在107分钟后达到最大值（3.4 °C）。（20-50 mg/kg）时，体温下降较少，与施用1-2 mg/kg后观察到的相似。2.对试验剂量2 mg/kg辣椒素的低温效应的敏感性降低，以及在用20-50 mg/kg的单剂量或分次施用50 mg/kg的辣椒素预处理后2周，在大鼠中发现对高环境温度的耐受性受损。50 mg/kg的辣椒素分次给药在不影响辣椒素预处理的脱敏作用的情况下有利于降低死亡率。3.单次给药后，低温期之后是剂量依赖性的高温期，持续至少2天。长期的热作用和辣椒素给药的脱敏作用之间的密切相关性也已建立。本文还对辣椒素的脱敏作用与热诱导作用之间的可能关系作了简要的讨论。
The hypothermic effect of capsaicin, the reduced responsiveness towards the hypothermic effect of the drug as well as the impairment of thermoregulation in a warm environment subsequent to the administration of different doses of capsaicin have been studied in rats. The mortality after capsaicin treatment has also been established.1.Capsaicin given subcutaneously in doses of 1–10 mg/kg induced a dose-dependent fall in body temperature lasting for 2–5 h. A single dose of 10 mg/kg caused the most pronounced hypothermic effect reaching its maximum (3,4°C) after 107 min. After higher doses (20–50 mg/kg) the fall in body temperature was less, being similar to that observed after the administration of 1–2 mg/kg.2.A decreased sensitivity towards the hypothermic effect of a test dose of 2 mg/kg capsaicin, as well as an impaired tolerance to high ambient temperature have been found in rats 2 weeks after the pretreatment either with a single dose of 20–50 mg/kg or fractionated administration of 50 mg/kg capsaicin. The fractionated administration of a dose of 50 mg/kg capsaicin proved to be beneficial in decreasing mortality without affecting the desensitizing effect of capsaicin pretreatment.3.After single doses of capsaicin the hypothermic period was followed by a dose-dependent hyperthermia which lasted for at least 2 days. A close correlation between the prolonged hyperthermic action and the desensitizing effect of capsaicin administration has also been established. The possible relationship between the desensitizing and hyperthermia inducing effect of capsaicin is briefly discussed.