Follow-up study of long-term survivors of osteosarcoma in the prechemotherapy era
Follow-up study of long-term survivors of osteosarcoma in the prechemotherapy era
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DOI：
10.1016/j.humpath.2006.02.022
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发表时间：
2006-08-01
期刊：
影响因子：
3.3
通讯作者：
Bolander, Mark E.
中科院分区：
文献类型：
--
作者：
Gaffney, Robyn;Unni, K. Krishnan;Bolander, Mark E.
骨肉瘤是最常见的原发性骨肉瘤。20世纪60年代发表的几项研究表明，大约五分之一的患者在仅接受手术治疗时存活。然而，没有关于骨肉瘤长期后果的信息。了解这些患者是否有发生第二种恶性肿瘤的风险尤其重要。我们回顾了1900年至1960年化疗前在马约诊所接受治疗的长期（定义为超过10年）骨肉瘤幸存者的所有临床记录。我们重新审查了大多数病例的组织切片。患者或近亲在电话访谈中提供随访信息。第二恶性肿瘤的发生率与一般人群的预期发生率进行了比较。我们确定了465例接受骨肉瘤治疗的患者。在这些患者中，83例（17.8%）为长期存活者，其中19例在治疗后存活长达65年。肺转移7例，死亡3例。26例患者发生第二种恶性肿瘤，其中15例死于恶性肿瘤。虽然骨肉瘤长期存活者的第二个恶性肿瘤的发生率高于正常人群，但这种增加没有统计学意义。没有人口统计学或组织学变量预测长期生存。(c)2006年爱思唯尔公司All rights reserved.
Osteosarcoma is the most common primary bone sarcoma. Several studies published in the 1960s established that approximately one fifth of patients survive when treated with surgery alone. There is no information, however, about the long-term consequences of osteosarcoma. It is especially relevant to know if these patients are at risk for a second malignancy. We reviewed all clinical records from long-term (defined as more than 10 years) osteosarcoma survivors treated at Mayo Clinic in the prechemotherapeutic era from 1900 to 1960. We re-reviewed histological sections for most cases. Patients or next of kin provided follow-up information during telephone interviews. Rates of second malignancy were compared with expected rates in the population at large. We identified 465 patients treated for osteosarcoma. Of these patients, 83 (17.8%) were long-term survivors, including 19 who were alive up to 65 years after treatment. Of the 7 patients with pulmonary metastases, 3 died. A second malignancy developed in 26 patients, 15 of whom died of the malignancy. Although long-term survivors of osteosarcoma have a higher incidence of a second malignant tumor than a normal population, this increase was not statistically significant. No demographic or histological variables predicted longterm survival. (c) 2006 Elsevier Inc. All rights reserved.