Cell-Mediated Cytotoxicity to Muscle in Polymyositis
Cell-Mediated Cytotoxicity to Muscle in Polymyositis
复制标题
多发性肌炎中细胞介导的肌肉细胞毒性
DOI：
--
复制
发表时间：
1973
期刊：
影响因子：
--
通讯作者：
F. Mastaglia
中科院分区：
文献类型：
--
作者：
R. Dawkins;F. Mastaglia
摘要应用51 Cr释放法定量检测多发性肌炎患者骨骼肌细胞的免疫损伤。淋巴细胞介导的肌毒性在9例活动性疾病患者中升高（p<0.001），但在4例非活动性疾病患者中正常。没有证据表明存在抗体介导的细胞毒性。在9名患者中，分析了活性组中淋巴细胞介导的肌肉毒性与治疗和免疫抑制的关系。对接受免疫抑制治疗的患者进行的7项试验显示，正常淋巴细胞介导的肌毒性值为1.0 ± 4.2%（平均值±标准差），而对免疫抑制治疗不足的患者进行的8项试验显示淋巴细胞介导的肌毒性升高：24.4 ± 10.6%，这两组之间存在显著差异（p < 0.001）。这些数据表明，多发性肌炎的发病机制涉及细胞介导的针对骨骼肌的免疫反应。
Abstract Immunologic injury to cultures of skeletal muscle was studied in patients with polymyositis by means of a 51Cr release method that allows quantitation of myocyte injury. Lymphocyte-mediated myotoxicity was elevated in a group of nine patients with active disease (p<0.001) but was normal in four patients with inactive disease. There was no evidence of antibody-mediated cytotoxicity. Lymphocyte-mediated myotoxicity in the active group was analyzed in relation to treatment and immunosuppression in six of the nine patients. Seven tests on patients on immunosuppressive therapy gave normal lymphocyte-mediated myotoxicity values of 1.0 ± 4.2 per cent (mean ± S.D.), whereas eight tests on patients who were on less than immunosuppressive therapy yielded elevated lymphocyte-mediated myotoxicity: 24.4 ± 10.6 per cent, with a significant difference between these two groups (p < 0.001). These data suggest that the pathogenesis of polymyositis involves a cell-mediated immunologic reaction directed against skel...