TELEMETRIC MONITORING OF CARDIOVASCULAR PARAMETERS IN CONSCIOUS SPONTANEOUSLY HYPERTENSIVE RATS
TELEMETRIC MONITORING OF CARDIOVASCULAR PARAMETERS IN CONSCIOUS SPONTANEOUSLY HYPERTENSIVE RATS
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DOI：
10.1097/00005344-199312000-00019
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发表时间：
1993-12-01
影响因子：
3
通讯作者：
WEBB, RL
中科院分区：
文献类型：
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作者：
BAZIL, MK;KRULAN, C;WEBB, RL
在自发性高血压大鼠(SHR)中，我们将遥测系统同时获得的心血管数值与外置导管记录的数值进行比较。我们还测试了远程监测减少与心血管研究表现相关的应激量的假设。在甲氧氟烷麻醉下植入股动脉导管和股静脉导管的男性SHR在38+/-7天前用无线电遥测装置植入。然后给大鼠1天的恢复时间，然后进行实验。使用遥测系统和股动脉导管获得的基线血压(BP)和心率(HR)值相似，静脉注射(IV.V.)给予苯肾上腺素(PE)、血管紧张素I(ANGI)、乙酰胆碱(ACh)或硝酸甘油(NTG)可引起相似的血压和心率变化。静脉注射诱发的血流动力学反应。硝苯地平的给药情况也与遥测监测和股动脉插管记录的相似。在仅用遥测设备测量的SHR的基线心血管参数中，BP和HR值始终显著低于尾袖或股动脉导管记录的值。此外，接受尾袖手术的自发性高血压患者对口服卡托普利的反应更严重，表现为低血压。这些研究表明，遥测监测清醒大鼠的心血管参数是一种灵敏、准确和灵活的方法。较低的基础心血管值和对血管紧张素转换酶(ACE)抑制的降压效应不敏感，表明压力水平的降低与无线电遥测系统进行的心血管研究的表现有关。
We compared cardiovascular values obtained with a telemetric system simultaneously with those recorded by an externalized catheter in spontaneously hypertensive rats (SHR). We also tested the hypothesis that telemetric monitoring reduces the amount of stress associated with performance of cardiovascular studies. Femoral arterial and venous catheters were implanted under methoxyflurane anesthesia in male SHR previously implanted 38 +/- 7 days earlier with radiotelemetric devices. Rats were then allowed 1 day to recover before undergoing experimentation. Baseline blood pressure (BP) and heart rate (HR) values obtained with the telemetric system and with the femoral arterial catheters were similar, and intravenous (i.v.) administration of phenylephrine (PE), angiotensin I (ANGI), acetylcholine (ACh), or nitroglycerin (NTG) evoked similar changes in BP and HR. Hemodynamic responses evoked by i.v. administration of nifedipine were also similar as recorded by telemetric monitoring and the femoral arterial cannula. Baseline cardiovascular parameters measured in SHR instrumented only with telemetric devices consistently yielded BP and HR values significantly lower than those recorded by tail-cuff or femoral catheters. In addition, SHR subjected to the tail-cuff procedure responded to oral administration of captopril with a greater degree of hypotension. These studies demonstrate that telemetric monitoring of cardiovascular parameters in conscious rats is a sensitive, accurate, and flexible method. The lower basal cardiovascular values and the insensitivity to the hypotensive effects of angiotensin-converting enzyme (ACE) inhibition, suggest that a decreased level of stress is associated with performance of cardiovascular studies by a radiotelemetric system.