Hormone ontogeny in the ovine fetus. I. Circulating growth hormone in mid and late gestation.
Hormone ontogeny in the ovine fetus. I. Circulating growth hormone in mid and late gestation.
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绵羊胎儿的激素个体发育。
作者：
P. Gluckman;P. L. Mueller;S. Kaplan;A. Rudolph;M. Grumbach
用同源放射免疫法测定了45例妊娠66天至足月(147天)的羊胎118例的OGH水平。妊娠60~70d血中GH浓度(148.0±9.6 ng/ml)较高，随后下降(49.0±7.3 ng/ml)，130~140d达高峰(150.4±10.5 ng/ml)，分娩前又下降至较低水平。在胎儿手术中获得的样本(n=63)中，也观察到类似的模式，但在妊娠120天后，36个血浆OGH值中有15个高于慢性组计算的正常范围的上限。在42个患有缺氧或酸中毒的胎儿样本中也观察到了类似的发现，这表明与应激相关的生长激素释放在妊娠晚期发生。母血GH水平与胎龄无关，在整个孕期处于较低水平(4.4±0.7 ng/ml)。这种模式..。
Ovine GH (oGH) was determined by homologous RIA on 118 samples from 45 chronically catheterized ovine fetuses from 66 days of gestation to term (147 days). A triphasic pattern of oGH concentration was demonstrated with high circulating GH concentrations (148.0 ± 9.6 ng/ml) at 60–70 days gestation, falling by 100–110 days (49.0 ± 7.3 ng/ml), increasing again to peak at 130-140 days (150.4 ± 10.5 ng/ml), and again decreasing to lower concentrations characteristic of the neonate before delivery. In samples obtained during fetal surgery (n = 63), a similar pattern was observed, but after 120 days of gestation, 15 of 36 plasma oGH values were above the upper limit of the normal range calculated from the chronic group. Similar findings were observed in 42 samples from fetuses that had developed hypoxia or acidosis, suggesting that stress-related GH release develops in late gestation. Maternal GH concentrations did not correlate with gestational age and were low throughout pregnancy (4.4 ± 0.7 ng/ml). The patter...