Plasma YKL-40 and Total and Disease-Specific Mortality in the General Population
Plasma YKL-40 and Total and Disease-Specific Mortality in the General Population
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DOI：
10.1373/clinchem.2010.146530
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发表时间：
2010-10-01
影响因子：
9.3
通讯作者：
Nordestgaard, Borge G.
中科院分区：
文献类型：
--
作者：
Johansen, Julia S.;Bojesen, Stig E.;Nordestgaard, Borge G.
背景：血浆YKL-40升高与心血管疾病和癌症患者的短期生存相关。我们检验了血浆YKL-40升高与总死亡率和疾病特异性死亡率相关的假设。方法：我们测量了8899名研究参与者的血浆YKL-40，年龄在20-95岁之间，在哥本哈根城市心脏研究中，来自丹麦的一般人群，随访16年：3059人死亡，2158人患有缺血性心血管疾病，2271人患有癌症，2820人患有与YKL-40增加相关的其他疾病。根据血浆YKL-40百分位数分组计算早期死亡和绝对10年死亡率的风险比，在性别和年龄10年内计算：0%-33%，34%-66%，67%-90%，91%-95%和96%-100%。血浆YKL-40水平为0%-33%的受试者的中位生存年龄从83岁降至96%-100%的受试者的69岁（趋势，P < 0.0001）。与YKL-40类别0%-33%相比，YKL-40类别34%-66%的早期死亡风险（多因素调整的风险比）增加10%，67%-90%增加30%，91%-95%增加70%，96%-100%增加90%（趋势，P < 0.0001）。缺血性心血管疾病患者的相应增加分别为10%、20%、80%和60%（P < 0.0001）;癌症患者分别为10%、20%、50%和70%（P < 0.0001）;其他疾病患者分别为10%、20%、40%和60%（P < 0.0001）。年龄>70岁、吸烟、YKL-40分类96%-100%.CONCLUSIONS：血浆YKL-40水平升高与一般人群中心血管疾病、癌症和其他疾病的早期死亡风险相关。(c)2010年美国临床化学协会
BACKGROUND: Increased plasma YKL-40 is associated with short-term survival in patients with cardiovascular disease and cancer. We tested the hypothesis that increased plasma YKL-40 is associated with total and disease-specific mortality in the general population.METHODS: We measured plasma YKL-40 in 8899 study participants, aged 20-95 years, in the Copenhagen City Heart Study from the Danish general population who were followed for 16 years: 3059 died, 2158 had ischemic cardiovascular disease, 2271 had cancer, and 2820 had other diseases associated with increased YKL-40. Hazard ratios for early death and absolute 10-year mortality rates were calculated according to plasma YKL-40 percentile groupings computed within sex and age decade: 0%-33%, 34%-66%, 67%-90%, 91%-95%, and 96%-100%.RESULTS: Median survival age decreased from 83 years for participants with plasma YKL-40 in category 0%-33% to 69 years in category 96%-100% (trend, P < 0.0001). Risk of early death was increased (multifactorially adjusted hazard ratios) by 10% for YKL-40 category 34%-66%, by 30% for 67%-90%, by 70% for 91%-95%, and by 90% for 96%-100% vs YKL-40 category 0%-33% (trend, P < 0.0001). Corresponding increases in participants with ischemic cardiovascular disease were 10%, 20%, 80%, and 60% (P < 0.0001); in those with cancer were 10%, 20%, 50%, and 70% (P < 0.0001); and in those with other diseases were 10%, 20%, 40%, and 60% (P < 0.0001). Highest absolute 10-year mortality rates were 78% and 90% in women and men, respectively, who were >70 years old, smoked, and were in YKL-40 category 96%-100%.CONCLUSIONS: Increased plasma YKL-40 is associated with risk of early death from cardiovascular disease, cancer, and other diseases in the general population. (c) 2010 American Association for Clinical Chemistry