Measuring SSRI occupancy of SERT using the novel tracer [123I]ADAM:: a SPECT validation study
Measuring SSRI occupancy of SERT using the novel tracer [123I]ADAM:: a SPECT validation study
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DOI：
10.1007/s00259-005-1912-y
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发表时间：
2005-11-01
影响因子：
9.1
通讯作者：
Ell, PJ
中科院分区：
文献类型：
--
作者：
Erlandsson, K;Sivananthan, T;Ell, PJ
Purpose: Serotonergic brain regions play a crucial role in the modulation of emotion, and serotonergic dysfunction may contribute to several neurological disorders. [I-123]ADAM is a novel SPECT tracer which binds with high affinity to serotonin transporters (SERT). The objective of this study was to compare different methods for the quantification of tracer binding and to develop a simplified single-scan protocol for this tracer, as well as to investigate its potential for characterisation of the transporter occupancy versus plasma concentration curve of a selective serotonin re-uptake inhibitor (SSRI).Methods: Dynamic SPECT scans were performed on 16 healthy volunteers after administration of similar to 150 MBq [I-123]ADAM. Data were acquired from the time of injection until
