Pergolide mesylate: a potent day-long inhibitor of prolactin in rhesus monkeys and patients with Parkinson's disease.
Pergolide mesylate: a potent day-long inhibitor of prolactin in rhesus monkeys and patients with Parkinson's disease.
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甲磺酸培高利特：恒河猴和帕金森病患者的有效一天催乳素抑制剂。
DOI：
10.1210/jcem-51-1-152
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
M. Kupersmith
中科院分区：
文献类型：
--
作者：
D. Kleinberg;A. Lieberman;Jean Todd;J. Greising;A. Neophytides;M. Kupersmith
新合成的麦角生物碱甲磺酸培高利特在4只恒河猴和3名帕金森病患者24小时内对PRL的抑制作用进行了评估。在猴子中，24小时内的平均PRL水平在50微克时下降到对照组的24%。每天1000微克培高利特和6.6%的对照组每天200微克培高利特，在24小时内绝大多数样品的PRL是不可测量的。此外，在治疗动物中没有观察到对照组中出现的明显的间歇性波动。在3例帕金森病患者中，培高利特治疗也导致24小时PRL的均匀抑制。在一名服用培高利特（100微克/天）的患者中，平均24小时PRL水平降至对照组的18%，另外两名分别服用200和600微克培高利特的患者，其治疗前平均PRL水平分别为4.1和7.4 ng/ml，在24小时内获得的任何血液样本中均未检测到PRL。这些数据证明培高利特在恒河猴和帕金森病患者中是一种有效的PRL抑制剂；这种效果在24小时内呈现信息。
The effect of a new synthetic ergot alkaloid, pergolide mesylate, on the inhibition of PRL during 24-h periods was evaluated in four rhesus monkeys and three patients with Parkinson's disease. In the monkeys, the mean PRL level during the 24-h period fell to 24% of control in response to 50 micrograms. With 1000 micrograms pergolide daily and to 6.6% of control with 200 micrograms pergolide daily, PRL was unmeasurable in the great majority of samples over 24 h. In addition, the marked episodic fluctuation in PRL occurring in controls was not observed in treated animals. In three patients with Parkinson's disease, treatment with pergolide also resulted in uniform 24-h suppression of PRL. In one patient on pergolide (100 micrograms/day), the mean 24-h PRL level fell to 18% of control, and in two other patients on 200 and 600 micrograms pergolide, respectively, whose mean PRL levels were 4.1 and 7.4 ng/ml, respectively, before treatment, no PRL was detected in any of the blood samples obtained during the 24-h periods. These data provide evidence that pergolide is a potent inhibitor of PRL in rhesus monkeys and in patients with Parkinson's disease; the effect is iniform over 24-h periods.