Association between Affective Temperaments and Bipolar Spectrum Disorders: Preliminary Perspectives from a Controlled Family Study
Association between Affective Temperaments and Bipolar Spectrum Disorders: Preliminary Perspectives from a Controlled Family Study
复制标题
情感气质与双相情感障碍之间的关联：来自受控家庭研究的初步观点
DOI：
10.1159/000322691
复制
发表时间：
2011
期刊：
影响因子：
3.6
通讯作者：
S. Praharaj
中科院分区：
文献类型：
--
作者：
S. Gandotra;D. Ram;J. Kour;S. Praharaj
背景资料：本研究旨在确定双相I型障碍患者的一级亲属（FDR）与对照组相比，双相谱系障碍（BSD）的气质基础。取样和方法：样本包括198名受试者，其中实验组33名双相I型先证者及其33名FDR，患者对照组33名精神分裂症先证者及其33名FDR，以及33名正常健康对照及其33名FDR。情感气质和BSD分别使用孟菲斯、比萨、巴黎和圣地亚哥自我问卷的气质评估和Ghaemi等人的标准[Can J Psychiatry 2002;47：125-134]进行评估。结果如下：在双相I型先证者的FDR中，27.3%的患者符合BSD的诊断，显著高于其他组（相对危险度= 6，95%CI = 1.74-20.69）。与对照组相比，双相先证者明显更易出现胸腺亢进（相对风险= 2，95% CI = 1.34-2.98），与正常对照组的FDR相比，双相先证者的FDR和患者对照组的FDR均明显更易出现胸腺亢进（相对风险= 1.52，95% CI = 0.93-2.51）。与无BSD的FDR（双相情感障碍患者）相比，BSD的FDR（双相情感障碍患者）具有显著更高的总易怒气质评分（平均差异= 2.07，95%CI = 0.64-3.50）。结论：我们的研究结果支持这样一个事实，即整个频谱的双极性在易感家庭中传播。高情绪的分级分布提示双相情感障碍患者FDR中双相情感的表达较轻。易怒的气质似乎是BSD发展的一个特定的脆弱性标志。
Background: The study aimed at determining the temperamental underpinnings of bipolar spectrum disorders (BSD) in the first-degree relatives (FDR) of patients with bipolar I disorder in comparison with control subjects. Sampling and Methods: The sample consisted of 198 subjects: 33 bipolar I probands and their 33 FDR in the experimental group, 33 schizophrenia probands and their 33 FDR in the patient control group, and 33 normal healthy controls and their 33 FDR. The affective temperament and the BSD were assessed using the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire and the criteria of Ghaemi et al. [Can J Psychiatry 2002;47:125–134], respectively. Results: Among the FDR of bipolar I probands, 27.3% satisfied the diagnosis of BSD, which was significantly higher than in the other groups (relative risk = 6, 95% CI = 1.74–20.69). Bipolar probands were significantly more hyperthymic as compared to controls (relative risk = 2, 95% CI = 1.34–2.98), and both the FDR of the bipolar and the FDR of the patient control groups were significantly more hyperthymic as compared to the FDR of the normal controls (relative risk = 1.52, 95% CI = 0.93–2.51). FDR (of bipolar patients) with BSD had a significantly higher total irritable temperament score as compared to FDR (of bipolar patients) without BSD (mean difference = 2.07, 95% CI = 0.64–3.50). Conclusions: Our findings support the fact that the whole spectrum of bipolarity is transmitted in susceptible families. The graded distribution of hyperthymia suggests it to be a milder expression of bipolarity in the FDR of bipolar patients. The irritable temperament appears to be a specific vulnerability marker for the development of BSD.
影响因子：
6.6
作者：
Mendlowicz, MV;Jean-Louis, G;Akiskal, HS
通讯作者：
Akiskal, HS
双相情感障碍的家族传播。
影响因子：
--
作者：
Rice,J;Reich,T;Andreasen,NC;Endicott,J;VanEerdewegh,M;Fishman,R;Hirschfeld,RM;Klerman,GL
通讯作者：
Klerman,GL