Central Sensitization Phenotypes in Post Acute Sequelae of SARS-CoV-2 Infection (PASC): Defining the Post COVID Syndrome.
Central Sensitization Phenotypes in Post Acute Sequelae of SARS-CoV-2 Infection (PASC): Defining the Post COVID Syndrome.
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DOI：
10.1177/21501327211030826
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发表时间：
2021-01
影响因子：
3.6
通讯作者：
Ganesh R
中科院分区：
文献类型：
--
作者：
Bierle DM;Aakre CA;Grach SL;Salonen BR;Croghan IT;Hurt RT;Ganesh R
根据对2019年11月至2020年8月期间在马约诊所罗切斯特接受评估的患者的分析，制定并实施COVID后综合征的描述标准。共确定了465名有COVID-19检测阳性史的患者，并审查了他们的医疗记录。经过专家小组利用德尔菲方法进行全面审查后，确定了42例（9%）病例在急性COVID-19消退后持续存在持续性中枢致敏（CS）症状，本文称为COVID后综合征（PoCoS）。在本报告中，我们描述了这些PoCoS患者的基线特征。在这42例PoCoS患者中，平均年龄为46.2岁（中位年龄为46.5岁）。疼痛（90%）、疲劳（74%）、呼吸困难（43%）和立位不耐受（38%）是最常见的症状。最初的14名患者的特征被用于通过中枢致敏性疾病专家小组改进的德尔菲法制定临床标准。这些标准随后被应用于确定另外28例疑似PoCoS病例。使用2名评审员系统分析与使用标准的一致性，所有28例病例均由评审员确定为很可能或可能病例。使用这些拟议的定义标准的评审员间一致性很高，科恩α为0.88。在这里，我们提出了我们认为是COVID后综合征的第一个定义标准。这些可能有助于这些患者的临床表型分析，用于靶向治疗和未来的研究。
To develop and implement criteria for description of post COVID syndrome based on analysis of patients presenting for evaluation at Mayo Clinic Rochester between November 2019 and August 2020. A total of 465 patients with a history of testing positive for COVID-19 were identified and their medical records reviewed. After a thorough review, utilizing the DELPHI methods by an expert panel, 42 (9%) cases were identified with persistent central sensitization (CS) symptoms persisting after the resolution of acute COVID-19, herein referred to as Post COVID syndrome (PoCoS). In this report we describe the baseline characteristics of these PoCoS patients. Among these 42 PoCoS patients, the mean age was 46.2 years (median age was 46.5 years). Pain (90%), fatigue (74%), dyspnea (43%), and orthostatic intolerance (38%) were the most common symptoms. The characteristics of an initial 14 patients were utilized for the development of clinical criteria via a modified Delphi Method by a panel of experts in central sensitization disorders. These criteria were subsequently applied in the identification of 28 additional cases of suspected PoCoS. A 2-reviewer system was used to analyze agreement with using the criteria, with all 28 cases determined to be either probable or possible cases by the reviewers. Inter-reviewer agreement using these proposed defining criteria was high with a Cohen’s alpha of .88. Here we present what we believe to be the first definitional criteria for Post COVID syndrome. These may be useful in clinical phenotyping of these patients for targeted treatment and future research.