Chemical structure and function of glycosphingolipids of Sphingomonas spp and their distribution among members of the α-4 subclass of Proteobacteria
Chemical structure and function of glycosphingolipids of Sphingomonas spp and their distribution among members of the α-4 subclass of Proteobacteria
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DOI：
10.1038/sj.jim.2900708
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发表时间：
1999-10-01
影响因子：
3.4
通讯作者：
Zähringer, U
中科院分区：
文献类型：
--
作者：
Kawahara, K;Kuraishi, H;Zähringer, U
鞘氨醇单胞菌属在系统发育上属于变形菌门的 α-4 亚类。它们的膜中含有鞘糖脂 (GSL)，而不是像其他革兰氏阴性细菌那样含有脂多糖 (LPS)。该属的模式种S. paucimobilis具有仅含有葡萄糖醛酸(GlcA)作为糖部分的GSL-1和含有含有GlcA的四糖的GSL-4A。 GSL-1和GSL-4A与外膜蛋白和磷脂一起形成少动链球菌的外膜。在外膜中，GSL 的定位和功能与其他革兰氏阴性细菌的 LPS 一样。与模式种密切相关的鞘氨醇单胞菌同时含有GSL-1和寡糖型GSL，例如GSL-4A，但其他鞘氨醇单胞菌属和变形菌α-4亚纲中的其他属仅含有GSL-1。介绍了 GSL-1 中脂肪酸和二氢鞘氨醇的结构变化。
Sphingomonas spp are phylogenetically placed in the alpha-4 subclass of Proteobacteria. They have glycosphingolipids (GSL) in their membranes instead of lipopolysaccharide (LPS) as in other Gram-negative bacteria. S. paucimobilis, the type species of the genus, has GSL-1, which contains only glucuronic acid (GlcA) as a sugar moiety, and GSL-4A, which contains a tetrasaccharide including GlcA. GSL-1 and GSL-4A form the outer membrane of S. paucimobilis with outer membrane proteins and phospholipids. In the outer membrane, GSLs are assumed to locate and function as does the LPS of other Gram-negative bacteria. Sphingomonas spp closely related to the type species contain both GSL-1 and the oligosaccharide-type GSL such as GSL-4A, but other Sphingomonas spp and other genera in the alpha-4 subclass of Proteobacteria contain only GSL-1. Structural variations of fatty acids and dihydrosphingosines in the GSL-1 are presented.