Faecal calprotectin: a novel test for the diagnosis of colorectal cancer?
Faecal calprotectin: a novel test for the diagnosis of colorectal cancer?
复制标题
粪便钙卫蛋白：诊断结直肠癌的新测试？
DOI：
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发表时间：
1993
影响因子：
1.9
通讯作者：
B. Roald
中科院分区：
文献类型：
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作者：
A. Røseth;J. Kristinsson;M. Fagerhol;H. Schjønsby;E. Aadland;K. Nygaard;B. Roald
钙卫蛋白是中性粒细胞中一种重要的胞浆蛋白，53 名结直肠癌患者中的 50 名、40 名结直肠息肉患者中的 32 名以及全部 18 名胃癌患者的粪便中钙卫蛋白的浓度升高。根治性手术后，除一名结直肠癌患者外，所有患者的粪便钙卫蛋白水平均恢复至正常范围。粪便中钙卫蛋白的稳定性简化了钙卫蛋白的测定。仅 5 g 的样品即可获得可靠的估计值。根据文献数据，对于胃肠道肿瘤的检测，钙卫蛋白检测似乎比潜血检测更好。
Calprotectin, a prominent cytosol protein in neutrophil granulocytes, was present in increased concentrations in stools from 50 of 53 patients with colorectal cancer, 32 of 40 patients with colorectal polyps, and all of 18 patients with gastric cancer. After radical surgery, faecal calprotectin levels reverted to the normal range in all but one patient with colorectal cancer. Calprotectin determinations are simplified by the stability of this protein in stools. Reliable estimates can be obtained in samples of only 5 g. On the basis of data from the literature, the test for calprotectin seems better than that for occult blood for the detection of gastrointestinal neoplasms.