13N-NH3 Versus F-18 FDG in Detection of Intracranial Meningioma Initial Report
13N-NH3 Versus F-18 FDG in Detection of Intracranial Meningioma Initial Report
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DOI：
10.1097/rlu.0b013e3182291c2a
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发表时间：
2011-11-01
影响因子：
10.6
通讯作者：
Chen Zhifeng
中科院分区：
文献类型：
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作者：
Zhang Xiangsong;Shi Xingchong;Chen Zhifeng
目的：据报道，所有类型的脑膜瘤都有相对较高的Tl-201摄取，并且已经提出（TlCl）-Tl-201 SPECT可以预测脑膜瘤的组织学类型并区分良性和侵袭性脑膜瘤。与Tl-201类似，N-13-NH 4+是K+的类似物，并且在某些情况下可以取代K+。方法：对11例经神经影像学诊断为脑膜瘤的患者进行N-13-NH3 PET检查，其中10例在3天内进行了F-18FDGPET检查。结果：11例脑膜瘤中N-13-NH3摄取均明显增高，与周围正常脑组织对比良好。相反，与对侧相比，所有7例I级脑膜瘤患者的F-18 FDG摄取均降低，其余II级脑膜瘤患者的F-18 FDG摄取中度增加。N-13-NH3的T/W比值高于F-18 FDG（7.03 ± 1.62 vs. 1.44 ± 0.57，P < 0.005）。N-13-NH3摄取的T/W对于区分良性（I级）和非典型性（I级）没有帮助。（II级）脑膜瘤F-18FDG摄取的T/W比值在良恶性脑膜瘤鉴别诊断中优于N-13-NH3（P = 0.88结论：与F-18 FDG相比，N-13-NH 3在脑膜瘤中的摄取相对较高。N-13-NH3 PET在脑膜瘤分级和随访中的临床应用需要进一步研究评估。
Purpose: Relatively high Tl-201 uptakes have been reported in all types of meningiomas, and it have been proposed that (TlCl)-Tl-201 SPECT could predict histologic types of meningiomas and differentiate the benign and aggressive meningiomas. Similar to Tl-201, N-13-NH4+ is an analog of K+ and could substitute K+ in some cases. The aim of this study was to evaluate the capacity of PET with N-13-NH3 to discriminate meningioma from healthy tissue, and compare with F-18 FDG.Methods: Eleven patients with the neuroradiologic diagnosis of meningiomas were studied with N-13-NH3, and 10 of them were performed with F-18 FDG PET within 3 days. Ten of them were histologically confirmed (6 grade I, 4 grade II), and another one was proved by radiologic (computed tomography and magnetic resonance imaging) and clinical investigation.The PET images were evaluated by semiquantitative analysis using tumor-to-white matter ratio (T/W).Results: N-13-NH3 uptake was obviously increased in all 11 meningiomas with a good contrast to the surrounding normal brain tissues. Conversely, F-18 FDG uptake was decreased in comparison with the contralateral side in all 7 patients with grade I meningiomas and moderately increased in the remaining patient with grade II meningioma. The T/W ratio of N-13-NH3 was higher than that of F-18 FDG (7.03 +/- 1.62 vs. 1.44 +/- 0.57, P < 0.005). T/W of N-13-NH3 uptake was not useful for differentiating benign (Grade I) from atypical (Grade II) meningiomas (P = 0.88), whereas the T/W ratio of F-18 FDG uptake was better than that of N-13-NH3 for differentiating benign from malignant meningiomas (P = 0.037).Conclusions: These preliminary results suggest that N-13-NH3 has relatively greater uptake in meningiomas in comparison with F-18 FDG. Clinical applications of N-13-NH3 PET for grading and follow-up of meningiomas need to be assessed in further studies.