Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results
Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results
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DOI：
10.1016/j.mri.2006.09.006
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发表时间：
2007-01-01
影响因子：
2.5
通讯作者：
Gore, John C.
中科院分区：
文献类型：
--
作者：
Yankeelov, Thomas E.;Lepage, Martin;Gore, John C.
Purpose: The objective of this study was to assess changes in the water apparent diffusion coefficient (ADC) and in pharmacokinetic parameters obtained from the fast-exchange regime (FXR) modeling of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) during neoadjuvant chemotherapy in breast cancer.Materials and Methods: Eleven patients with locally advanced breast cancer underwent MRI examination prior to and after chemotherapy but prior to surgery. A 1.5-T scanner was used to obtain T-1, ADC and DCE-MRI data. DCE-MRI data were analyzed by the FXR model returning estimates of K-trans (volume transfer constant), v(e) (extravascular extracellular volume fraction) and tau(i) (average intracellular water lifetime).直方图和相关分析评估了治疗后参数的变化。结果：显着（P
Purpose: The objective of this study was to assess changes in the water apparent diffusion coefficient (ADC) and in pharmacokinetic parameters obtained from the fast-exchange regime (FXR) modeling of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) during neoadjuvant chemotherapy in breast cancer.Materials and Methods: Eleven patients with locally advanced breast cancer underwent MRI examination prior to and after chemotherapy but prior to surgery. A 1.5-T scanner was used to obtain T-1, ADC and DCE-MRI data. DCE-MRI data were analyzed by the FXR model returning estimates of K-trans (volume transfer constant), v(e) (extravascular extracellular volume fraction) and tau(i) (average intracellular water lifetime). Histogram and correlation analyses assessed parameter changes post-treatment.Results: Significant (P