Synthesis of Novel Peptide Linkers: Simultaneous Cyclization and Labeling
Synthesis of Novel Peptide Linkers: Simultaneous Cyclization and Labeling
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DOI：
10.1021/ol901662c
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发表时间：
2009-10-15
期刊：
影响因子：
5.2
通讯作者：
Hartman, Matthew C. T.
中科院分区：
文献类型：
--
作者：
Dewkar, Gajanan K.;Carneiro, Pedro B.;Hartman, Matthew C. T.
在二异丙基乙胺存在下，通过1，3，5-三（溴甲基）苯与多种羧酸的单羧化反应合成新型肽接头。这些试剂可用于同时环化和标记含有两个半胱氨酸的肽。许多标记与该方法相容，包括脂质、荧光基团和生物素。
Synthesis of novel peptide linkers was accomplished by monocarboxylation of 1,3,5-tris(bomomethyl)benzene with a wide variety of carboxylic acids in the presence of diisopropylethylamine. These reagents can be used to simultaneously cyclize and label peptides containing two cysteines. Many labels are compatible with this method including lipids, fluorescent groups, and biotin.