CSF smooth-muscle constrictor activity associated with cerebral vasospasm and mortality in SAH patients.
CSF smooth-muscle constrictor activity associated with cerebral vasospasm and mortality in SAH patients.
复制标题
脑脊液平滑肌收缩活性与 SAH 患者脑血管痉挛和死亡率相关。
DOI：
10.3171/jns.1984.60.5.0927
复制
发表时间：
1984
影响因子：
4.1
通讯作者：
D. Boullin
中科院分区：
文献类型：
--
作者：
A. Kaye;P. Tagari;P. Teddy;C. Adams;W. P. Blaso;D. Boullin
Cerebrospinal fluid (CSF) was collected preoperatively (by lumbar puncture) or perioperatively (by lumbar or ventricular drain) from 32 patients with subarachnoid hemorrhage (SAH) from ruptured intracranial aneurysms. Samples were also obtained from six control patients without evidence of subarachnoid blood. Smooth-muscle constrictor activity in the CSF was measured by bioassay using the isolated rat stomach fundus preparation. Concentrations of unidentified smooth-muscle constrictor substances were considerably greater in CSF from a group of seven patients with evidence of severe angiographic vasospasm and/or delayed ischemic deficits who died (73.8 +/- 39.7 nmol/liter prostaglandin E2 (PGE2) equivalents), as compared to 25 other SAH patients who survived (6.5 +/- 1.4 nmol/liter PGE2 equivalents), and six control patients (1.17 +/- 0.34 nmol/liter PGE2 equivalents). The data suggest that there is a relationship between smooth-muscle constrictor substances in the CSF after SAH and both the degree of angiographic vasospasm and the outcome. It is possible that this relationship might be exploited clinically.
