MRI and histological evaluation of the infiltrative growth pattern of myxofibrosarcoma
MRI and histological evaluation of the infiltrative growth pattern of myxofibrosarcoma
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DOI：
10.1007/s00256-008-0542-4
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发表时间：
2008-12-01
影响因子：
2.1
通讯作者：
Yamashita, Toshihiko
中科院分区：
文献类型：
--
作者：
Kaya, Mitsunori;Wada, Takuro;Yamashita, Toshihiko
目的粘液纤维肉瘤在MRI上常表现为沿着筋膜平面的异常信号浸润。材料与方法回顾性分析21例粘液纤维肉瘤的临床、病理及影像学资料。所有肿瘤呈弥漫浸润性生长，表现为不典型细胞向肌筋膜无边界延伸，伴中度核扩散。值得注意的是，其余4例病灶生长模式的MRI也表现出浸润性生长模式的组织学表明，粘液纤维肉瘤显示浸润性生长的属性，即使在缺乏浸润性生长模式的MRI。结论大多数粘液纤维肉瘤显示浸润性生长模式的组织学。骨科肿瘤学家应仔细注意准确评估肿瘤的扩展。尽可能切除MRI上观察到的整个异常信号延伸区域似乎是明智的，以获得足够的粘液纤维肉瘤手术切缘。
Objective Myxofibrosarcoma often shows abnormal signal infiltration along the fascial plane on magnetic resonance imaging (MRI). The objective was to describe this MRI characteristic of myxofibrosarcoma with pathologic findings for comparison.Materials and methods Clinical, histological, and imaging data for 21 patients with myxofibrosarcoma were reviewed retrospectively.Results Seventeen tumors showed a diffuse infiltrative pattern on MRI. All tumors with diffuse infiltrative growth pattern showed borderless extension of atypical cells with moderate nuclear atypia to the muscle fascia. Notably, the remaining four patients with focal growth pattern on MRI also demonstrated infiltrative growth pattern histologically suggesting that myxofibrosarcoma shows an infiltrative growth property even in the lack of infiltrative growth pattern on MRI.Conclusion Most myxofibrosarcoma show an infiltrative growth pattern histologically. Orthopedic oncologist should pay careful attention to accurately assess tumor extension. It seems prudent to resect the entire area of abnormal signal extension seen on MRI whenever possible to obtain an adequate surgical margin of myxofibrosarcoma.