Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development.
Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development.
复制标题
DOI：
10.1155/2017/9173090
复制
发表时间：
2017
影响因子：
4.6
通讯作者：
González-Arenas A
中科院分区：
文献类型：
--
作者：
Valdés-Rives SA;González-Arenas A
Lysophosphatidic acid (LPA) is a ubiquitous lysophospholipid and one of the main membrane-derived lipid signaling molecules. LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA1–6, to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. LPA receptors and autotaxin (ATX), a secreted phosphodiesterase that produces this phospholipid, are overexpressed in many cancers and impact several features of the disease, including cancer-related inflammation, development, and progression. Many ongoing studies aim to understand ATX-LPA axis signaling in cancer and its potential as a therapeutic target. In this review, we discuss the evidence linking LPA signaling to cancer-related inflammation and its impact on cancer progression.
登录
查看更多内容
影响因子：
8.8
作者：
通讯作者：
--
自分泌运动因子-溶血磷脂酸轴在癌症对化疗和放疗的抵抗中的作用。
DOI：
10.1016/j.bbalip.2012.08.015
发表时间：
2013-01
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Brindley DN;Lin FT;Tigyi GJ
通讯作者：
Tigyi GJ
影响因子：
3.5
作者：
Bandoh, K;Aoki, J;Inoue, K
通讯作者：
Inoue, K
影响因子：
4.8
作者：
Benesch, Matthew G. K.;Tang, Xiaoyun;Brindley, David N.
通讯作者：
Brindley, David N.
影响因子：
62.1
作者：
Blaho, Victoria A.;Hla, Timothy
通讯作者：
Hla, Timothy