Age-associated declining of the regeneration potential of skeletal stem/progenitor cells.
Age-associated declining of the regeneration potential of skeletal stem/progenitor cells.
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DOI：
10.3389/fphys.2023.1087254
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发表时间：
2023
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
作者：
骨折在世界范围内是一个重大的健康负担，主要是因为老年人人数不断增加。随着人们年龄的增长，骨折的风险和频率急剧增加。这种增加源于骨骼完整性的丧失，也与骨再生潜力的降低有关。骨骼完整性丧失和再生潜力降低的核心是骨骼干/祖细胞（SSPCs），因为它们负责骨组织的生长、再生和修复。然而，sspc的确切身份尚未确定。因此，它们在衰老过程中的功能，尤其是功能障碍，从未被完全描述过。在这篇综述中，以描述SSPCs与衰老相关的功能障碍为最终目标，我们首先讨论了一些关于SSPCs鉴定的最新发现。然后，我们将重点关注SSPCs如何参与正常的骨再生过程，以及衰老如何改变其再生潜力，最终导致与年龄相关的骨折和缺乏修复。基于我们的经验也提供了新的观点。
Bone fractures represent a significant health burden worldwide, mainly because of the rising number of elderly people. As people become older, the risk and the frequency of bone fractures increase drastically. Such increase arises from loss of skeletal integrity and is also associated to a reduction of the bone regeneration potential. Central to loss of skeletal integrity and reduction of regeneration potential are the skeletal stem/progenitor cells (SSPCs), as they are responsible for the growth, regeneration, and repair of the bone tissue. However, the exact identity of the SSPCs has not yet been determined. Consequently, their functions, and especially dysfunctions, during aging have never been fully characterized. In this review, with the final goal of describing SSPCs dysfunctions associated to aging, we first discuss some of the most recent findings about their identification. Then, we focus on how SSPCs participate in the normal bone regeneration process and how aging can modify their regeneration potential, ultimately leading to age-associated bone fractures and lack of repair. Novel perspectives based on our experience are also provided.
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影响因子：
13.1
作者：
Burkhalter MD;Rudolph KL;Sperka T
通讯作者：
Sperka T
影响因子：
64.5
作者：
Baryawno, Ninib;Przybylski, Dariusz;Scadden, David T.
通讯作者：
Scadden, David T.
影响因子：
7.2
作者：
Visvader JE;Smith GH
通讯作者：
Smith GH
影响因子：
82.9
作者：
Farr JN;Xu M;Weivoda MM;Monroe DG;Fraser DG;Onken JL;Negley BA;Sfeir JG;Ogrodnik MB;Hachfeld CM;LeBrasseur NK;Drake MT;Pignolo RJ;Pirtskhalava T;Tchkonia T;Oursler MJ;Kirkland JL;Khosla S
通讯作者：
Khosla S
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J