Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: a study in 48 440 adult patients
Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: a study in 48 440 adult patients
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DOI：
10.1136/bjsports-2021-104080
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发表时间：
2021-10-01
影响因子：
18.4
通讯作者：
Cohen, Deborah A.
中科院分区：
文献类型：
--
作者：
Sallis, Robert;Young, Deborah Rohm;Cohen, Deborah A.
目的比较持续不活动、进行一些活动或持续遵守身体活动指南的COVID-19患者的住院率、重症监护病房（ICU）入院率和死亡率。方法选取2020年1月1日至2020年10月21日诊断为COVID-19的成年患者48440例，2018年3月19日至2020年3月18日至少进行了三次运动生命体征测量。我们将每位患者自我报告的身体活动类别（持续不活动=0-10分钟/周，一些活动=11-149分钟/周，持续满足指南=150+分钟/周）与COVID-19诊断后住院、ICU住院和死亡的风险联系起来。我们进行了多变量逻辑回归，控制人口统计学和已知危险因素，以评估不运动是否与COVID-19结局相关。结果：持续不活动的COVID-19患者与持续遵守身体活动指南的患者相比，因COVID-19住院（OR 2.26; 95% CI 1.81至2.83）、进入ICU （OR 1.73; 95% CI 1.18至2.55）和死亡（OR 2.49; 95% CI 1.33至4.67）的风险更高。与进行一些体育锻炼的患者相比，持续不运动的患者因COVID-19住院（OR 1.20; 95% CI 1.10至1.32）、进ICU （OR 1.10; 95% CI 0.93至1.29）和死亡（OR 1.32; 95% CI 1.09至1.60）的风险也更高。结论：在受感染的成年人中，持续遵守身体活动指南与降低COVID-19严重结局的风险密切相关。我们建议公共卫生机构优先促进体育活动，并将其纳入日常医疗保健。
Objectives To compare hospitalisation rates, intensive care unit (ICU) admissions and mortality for patients with COVID-19 who were consistently inactive, doing some activity or consistently meeting physical activity guidelines. Methods We identified 48 440 adult patients with a COVID-19 diagnosis from 1 January 2020 to 21 October 2020, with at least three exercise vital sign measurements from 19 March 2018 to 18 March 2020. We linked each patient's self-reported physical activity category (consistently inactive=0-10 min/week, some activity=11-149 min/week, consistently meeting guidelines=150+ min/week) to the risk of hospitalisation, ICU admission and death after COVID-19 diagnosis. We conducted multivariable logistic regression controlling for demographics and known risk factors to assess whether inactivity was associated with COVID-19 outcomes. Results Patients with COVID-19 who were consistently inactive had a greater risk of hospitalisation (OR 2.26; 95% CI 1.81 to 2.83), admission to the ICU (OR 1.73; 95% CI 1.18 to 2.55) and death (OR 2.49; 95% CI 1.33 to 4.67) due to COVID-19 than patients who were consistently meeting physical activity guidelines. Patients who were consistently inactive also had a greater risk of hospitalisation (OR 1.20; 95% CI 1.10 to 1.32), admission to the ICU (OR 1.10; 95% CI 0.93 to 1.29) and death (OR 1.32; 95% CI 1.09 to 1.60) due to COVID-19 than patients who were doing some physical activity. Conclusions Consistently meeting physical activity guidelines was strongly associated with a reduced risk for severe COVID-19 outcomes among infected adults. We recommend efforts to promote physical activity be prioritised by public health agencies and incorporated into routine medical care.