LEFT-VENTRICULAR HYPERTROPHY - EPIDEMIOLOGIC PROGNOSIS AND ASSOCIATED CRITICAL FACTORS
LEFT-VENTRICULAR HYPERTROPHY - EPIDEMIOLOGIC PROGNOSIS AND ASSOCIATED CRITICAL FACTORS
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DOI：
10.1093/eurheartj/14.suppl_d.16
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发表时间：
1993-07-01
影响因子：
39.3
通讯作者：
DALLOCCHIO, M
中科院分区：
文献类型：
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作者：
GOSSE, P;DALLOCCHIO, M
左心室肥大（LVH），定义为左心室质量（LVM）的异常增加，在16-19%的普通人群中通过超声心动图检测到。其患病率与年龄、收缩压和肥胖密切相关。除了评价左心室质量外，超声心动图还可以描述高血压患者不同形式的左心室重构：偏心性或同心性，对称性或不对称性LVH。然而，不同形式的意义尚未得到很好的界定。左心室质量增加现在被认为是所有心血管疾病的一个强大的独立危险因素。这一观察结果与LVH是左心室对慢性超负荷的有效适应的一般概念不一致。为了解释这一悖论，提出了三个假设：LVH作为一个标志，一个有限的适应过程，或一个病理过程。每种假说都意味着不同的治疗方法：因此有必要阐明LVH是如此重要的危险因素的原因。
Left ventricular hypertrophy (LVH), defined as an abnormal increase in left ventricular mass (LVM), is detected by echocardiography in 16–19% of a general population. Its prevalence is strongly associated with age, systolic blood pressure and obesity. In addition to the assessment of LVM, echocardiography allows different forms of left ventricular remodelling in hypertension to be described: eccentric or concentric, and symmetric or asymmetric LVH. The significance of the different forms, however, is not yet well defined. Increased LVM is now recognized as a powerful, independent risk factor for all cardiovascular diseases. This observation is at variance with tjie general concept that LVH is a useful adaptation of the left ventricle to chronic overload. To explain this paradox, three hypotheses are proposed: LVH serves as a marker, a limited adaptative process, or a pathological process. Each hypothesis implies different therapeutic approaches: thus it is necessary to clarify the reasons why LVH is such an important risk factor.