A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth
A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth
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DOI：
10.1021/acsnano.8b09573
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发表时间：
2019-04-01
期刊：
影响因子：
17.1
通讯作者：
Gu, Zhen
中科院分区：
文献类型：
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作者：
Yang, Guang;Chen, Qian;Gu, Zhen
激活毛囊干细胞(HfSCs)以促进毛囊再生有望为脱发治疗带来希望，而开发一种能够提高治疗效率和易于给药的方案仍然存在挑战。在这里，我们描述了一种可拆卸的微针贴片介导的药物传递系统，主要由毛发来源的角蛋白制成，用于持续传递HFSC激活剂。在小鼠模型中，这种微针装置与间充质干细胞(MSC)来源的外切体和小分子药物UK5099相结合，可以在较小的剂量下提高治疗效率，导致6天内促进色素沉着和毛发再生。这种基于微针的经皮给药方法显示出比皮下注射外切体和局部给药UK5099更有效的效果。
Activating hair follicle stem cells (HFSCs) to promote hair follicle regrowth holds promise for hair loss therapy, while challenges still remain to develop a scenario that enables enhanced therapeutic efficiency and easy administration. Here we describe a detachable microneedle patch-mediated drug delivery system, mainly made from hair-derived keratin, for sustained delivery of HFSC activators. It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model. This microneedle-based transdermal drug delivery approach shows augmented efficacy compared to the subcutaneous injection of exosomes and topical administration of UK5099.