Stimulant effects of 3,4-methylenedioxymethamphetamine in the nucleus accumbens of rat.
Stimulant effects of 3,4-methylenedioxymethamphetamine in the nucleus accumbens of rat.
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3,4-亚甲二氧基甲基苯丙胺对大鼠伏核的刺激作用。
DOI：
10.1016/0014-2999(92)90094-k
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发表时间：
1992
影响因子：
5
通讯作者：
Geyer,MA
中科院分区：
文献类型：
--
作者：
Callaway,CW;Geyer,MA
本研究采用自动化洞板和旷场装置研究了S（+）-3，4-亚甲二氧基甲基苯丙胺（S-MDMA）脑内给药对大鼠行为的影响。将S-MDMA注入隔核可产生运动过度活跃。虽然氟西汀预处理可拮抗全身给予S-MDMA的兴奋作用，但氟西汀不拮抗给予丘脑核S-MDMA的激活作用。S-安非他明给药后，观察到类似的增加自发活动的神经核。相比之下，选择性5-HT释放药物和S-MDMA同系物N-甲基-1-（1，3-苯并二氧杂环戊烯-5-基）-2-丁胺（MBDB）在全身给药时产生MDMA样运动机能亢进，但在注射到延髓核时不改变运动活性。这些数据表明，S-MDMA在丘脑核中的作用与系统给予S-MDMA的主要作用截然不同。S-MDMA在丘脑核中的行为效应可能是由于S-MDMA与S-苯丙胺共享的释放儿茶酚胺的特性，而不是通过它与MBDB共享的释放5 HT的特性。
This study examined the behavioral effects in rats of intracerebral administration of S(+)-3,4-methylenedioxymethamphetamine (S-MDMA) using an automated holeboard and open-field apparatus. Administration of S-MDMA into the nucleus accumbens septi produced locomotor hyperactivity. Although the stimulant effects of S-MDMA administered systemically are antagonized by fluoxetine pretreatment, the activating effects of S-MDMA administered into the nucleus accumbens were not antagonized by fluoxetine. A similar increase in locomotor activity was observed after S-amphetamine administration into the nucleus accumbens. In contrast, the selective 5-HT-releasing drug and S-MDMA congener N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine (MBDB) produces MDMA-like locomotor hyperactivity when administered systemically but did not alter locomotor activity when injected into the nucleus accumbens. These data indicate that S-MDMA actions in the nucleus accumbens are pharmacologically distinct from the primary effects of systematically administered S-MDMA. Behavioral effects of S-MDMA in the nucleus accumbens may result from the catecholamine-releasing properties that S-MDMA shares with S-amphetamine and not via the 5HT-releasing properties that it shares with MBDB.