Corticotropin-releasing factor antagonist attenuates defensive-withdrawal behavior elicited by odors of stressed conspecifics.
Corticotropin-releasing factor antagonist attenuates defensive-withdrawal behavior elicited by odors of stressed conspecifics.
复制标题
促肾上腺皮质激素释放因子拮抗剂可减弱由应激同种的气味引起的防御性退缩行为。
DOI：
10.1037//0735-7044.104.2.386
复制
发表时间：
1990
影响因子：
1.9
通讯作者：
Baker,EW
中科院分区：
文献类型：
--
作者：
Takahashi,LK;Kalin,NH;Baker,EW
本研究探讨了生物源性威胁刺激引起的防御反应是由内源性促肾上腺皮质激素释放因子（CRF）介导的。将大鼠暴露在一个大开阔的场地上15分钟，场地内有一个小房间。24小时后，大鼠脑室内注射载体或20 μg α-螺旋CRF(9-41)，一种CRF受体拮抗剂。20分钟后，大鼠再次暴露在开放的场地中，现在有来自应激同种动物的尿液和粪便的气味。在再暴露试验中，给药和拮抗剂的大鼠迅速退回到室内。然而，拮抗剂治疗的大鼠随后从室中出现，探索开放区域，这表明在室和开放区域之间的通道数量显着增加。结果表明，中枢注射α-螺旋CRF（9-41）可降低与威胁相关的气味引起的恐惧水平。此外，CRF受体还参与介导防御性退缩行为的物种典型表现。（PsycINFO数据库记录(c) 2016 APA，版权所有）
This study examined the hypothesis that defensive responsiveness induced by threatening stimuli of biological origin is mediated by the action of endogenous corticotropin-releasing factor (CRF). Rats were exposed for 15 min to a large open field containing a small chamber. Twenty-four hours later, rats received intracerebroventricular injections of either vehicle or 20 μg of α-helical CRF (9–41), a CRF receptor antagonist. After 20 min, rats were reexposed to the open field, which now contained odors of urine and feces from a stressed conspecific. In the reexposure test, vehicle-and antagonist-treated rats withdrew rapidly into the chamber. Antagonist-treated rats, however, emerged subsequently from the chamber to explore the open field as indicated by a significant increase in the number of passages made between the chamber and the open field. Results suggest that central injection of α-helical CRF (9–41) reduces the level of fear induced by odors associated with threat. In addition, CRF receptors are implicated in mediating the species-typical display of defensive withdrawal behavior.(PsycINFO Database Record (c) 2016 APA, all rights reserved)