Estimating the impact of alcohol consumption on survival for HIV plus individuals
Estimating the impact of alcohol consumption on survival for HIV plus individuals
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DOI：
10.1080/09540120601095734
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发表时间：
2007-01-01
影响因子：
1.7
通讯作者：
Justice, A. C.
中科院分区：
文献类型：
--
作者：
Braithwaite, R. S.;Conigliaro, J.;Justice, A. C.
饮酒与抗逆转录病毒治疗依从性降低相关，依从性降低导致预后较差。然而，酒精对生存的影响程度尚不清楚。我们的目标是使用校准和验证的艾滋病毒疾病模拟来估计酒精对生存的影响。我们在一个大型观察性队列（N = 2，702）中纳入了描述饮酒和依从性之间的时间和剂量-反应关系的临床数据。个人被分为不饮酒者（不饮酒），危险饮酒者（饮酒日消费≥ 5标准饮料）和非危险饮酒者（消费
Alcohol consumption is associated with decreased antiretroviral adherence, and decreased adherence results in poorer outcomes. However the magnitude of alcohol's impact on survival is unknown. Our objective was to use a calibrated and validated simulation of HIV disease to estimate the impact of alcohol on survival. We incorporated clinical data describing the temporal and dose- response relationships between alcohol consumption and adherence in a large observational cohort ( N = 2,702). Individuals were categorized as nondrinkers ( no alcohol consumption), hazardous drinkers ( consume >= 5 standard drinks on drinking days), and nonhazardous drinkers ( consume