A Facile Method for the Synthesis of 3-Alkyloxindole
A Facile Method for the Synthesis of 3-Alkyloxindole
复制标题
3-烷基吲哚的简易合成方法
DOI：
10.2174/157017812800167420
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发表时间：
2012-03-01
影响因子：
0.8
通讯作者：
Zhou, Jian
中科院分区：
文献类型：
--
作者：
Du, Tai-Ping;Zhu, Gang-Guo;Zhou, Jian
苄胺与乙酸的组合被认为是羟吲哚与醛、丙酮或环酮缩合的强大催化剂。通过连续乙酸苄胺催化的羟吲哚与醛（或酮）的缩合以及 NaBH4 的共轭还原，可以很容易地制备 10 mmol 规模的各种 3-烷基羟吲哚
Benzylamine in combination with acetic acid was identified as a powerful catalyst for the condensation of oxindole with aldehydes, acetone or cyclic ketones. A variety of 3-alkyloxindoles could be readily prepared in 10 mmol scale via the sequential benzylamine acetate catalyzed condensation of oxindoles with aldehydes (or ketones) and conjugate reduction by NaBH4