Thyroid carcinoma distinctively expresses intracellular fibronectin in vivo.
Thyroid carcinoma distinctively expresses intracellular fibronectin in vivo.
复制标题
甲状腺癌在体内独特地表达细胞内纤连蛋白。
DOI：
10.1016/s0304-3835(97)00353-4
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发表时间：
1997
期刊：
影响因子：
9.7
通讯作者：
S. Takebayashi
中科院分区：
文献类型：
--
作者：
S. Ryu;S. Jimi;S. Takebayashi
纤连蛋白是一种多功能蛋白质，在肿瘤侵袭中起作用。我们用免疫组化方法检测了纤维连接蛋白在甲状腺癌中的体内表达，并与其他癌如肝细胞癌、移行细胞癌和胃腺癌进行了比较。纤维连接蛋白在甲状腺癌细胞内的定位几乎所有的情况下发现。而肝细胞癌的表达率较低，其他癌均为阴性。这些结果表明，纤维连接蛋白的细胞内表达不是一个常见的现象，在甲状腺癌，而是独特的。
Fibronectin is a multifunctional protein that plays a role in tumor invasion. We immunohistochemically examined the in vivo expression of fibronectin in thyroid carcinoma in comparison with other carcinomas, such as hepatocellular carcinoma, transitional cell carcinoma and gastric adenocarcinoma. Intracellular localization of fibronectin was found in almost all cases of thyroid carcinoma. In contrast, hepatocellular carcinoma showed a lower expression rate and the other carcinomas were all negative. These results indicate that the intracellular expression of fibronectin is not a common phenomenon in carcinoma, but rather is distinctive for thyroid carcinoma.