Omega-3 fatty acid supplementation in patients with recurrent self-harm - Single-centre double-blind randomised controlled trial
Omega-3 fatty acid supplementation in patients with recurrent self-harm - Single-centre double-blind randomised controlled trial
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DOI：
10.1192/bjp.bp.106.022707
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发表时间：
2007-02-01
影响因子：
10.5
通讯作者：
Garland, Malcolm R.
中科院分区：
文献类型：
--
作者：
Hallahan, Brian;Hibbeln, Joseph R.;Garland, Malcolm R.
研究背景：临床试验已经证明了补充长链ω-3必需脂肪酸（n-3 EFA）对多种精神疾病的益处，目的是评估n-3 EFA在改善反复自我伤害患者心理健康方面的疗效。在标准精神病治疗的基础上，随机分配22例患者接受1.2 g二十碳五烯酸加0.9 g二十二碳六烯酸治疗，27例患者接受安慰剂治疗，治疗12周。6个心理领域进行了测量，在基线和endpoint.Results在12周，n-3 EFA组有显着更大的改善，抑郁，自杀和日常压力的分数。分数冲动，侵略和敌意没有different.Conclusions补充实现了大幅减少自杀行为的替代标记物和幸福感的改善。需要进行更大规模的研究以确定n-3 EFA的饮食摄入不足是否是自我伤害的可逆风险因素。利益声明Pronova（现为Epax）AS，Lysaker，Norway，提供了活性制剂和安慰剂，但没有参与本研究。
Background Trials have demonstrated benefits of long-chain omega-3 essential fatty acid (n-3 EFA) supplementation in a variety of psychiatric disorders.Aims To assess the efficacy of n-3 EFAs in improving psychological well-being in patients with recurrent self-harm.Method Patients (n=49) presenting after an act of repeated self-harm were randomised to receive 1.2 g eicosapentaenoic acid plus 0.9 g decosahexaenoic acid (n=22) or placebo (n=27) for 12 weeks in addition to standard psychiatric care. Six psychological domains were measured at baseline and end point.Results At 12 weeks, the n-3 EFA group had significantly greater improvements in scores for depression, suicidality and daily stresses. Scores for impulsivity, aggression and hostility did not differ.Conclusions Supplementation achieved substantial reductions in surrogate markers of suicidal behaviour and improvements in well-being. Larger studies are warranted to determine if insufficient dietary intake of n-3 EFAs is a reversible risk factor for self-harm.Declaration of interest Pronova (now Epax) AS, Lysaker, Norway, provided the active preparation and placebo but were not otherwise involved in the study Funding detailed in Acknowledgements.