Cannabinoid pharmacology: the first 66 years
Cannabinoid pharmacology: the first 66 years
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DOI：
10.1038/sj.bjp.0706406
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发表时间：
2006-01-01
影响因子：
7.3
通讯作者：
Pertwee, RG
中科院分区：
文献类型：
--
作者：
Pertwee, RG
简要回顾了20世纪40年代在大麻中首次发现大麻素的几十年后开始的个别大麻素的药理学研究。还介绍了这种药理学研究如何导致发现大麻素CB1和CB2受体以及这些受体的内源性配体，开发CB1和CB2选择性激动剂和拮抗剂，并认识到内源性大麻素系统在健康和疾病中都具有重要作用，以及模拟、增强或阻断内源性大麻素释放的作用的药物必须具有重要的治疗应用。确定了未来研究的一些目标。
Research into the pharmacology of individual cannabinoids that began in the 1940s, several decades after the presence of a cannabinoid was first detected in cannabis, is concisely reviewed. Also described is how this pharmacological research led to the discovery of cannabinoid CB1 and CB2 receptors and of endogenous ligands for these receptors, to the development of CB1- and CB2-selective agonists and antagonists and to the realization that the endogenous cannabinoid system has significant roles in both health and disease, and that drugs Which mimic, augment or block the actions of endogenously released cannabinoids must have important therapeutic applications. Some goals for future research are identified.