Instructable Nanoparticles Using Dynamic Combinatorial Chemistry
Instructable Nanoparticles Using Dynamic Combinatorial Chemistry
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DOI：
10.1021/acs.langmuir.5b03673
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发表时间：
2015-11-24
期刊：
影响因子：
3.9
通讯作者：
Otto, Sijbren
中科院分区：
文献类型：
--
作者：
Han, Yang;Nowak, Piotr;Otto, Sijbren
纳米粒子在生物大分子多价识别或程序化自组装中的应用需要控制其表面化学基团的相对位置。我们已经开发了一种方法来指导功能化的表面的修饰装备金纳米粒子使用的DNA模板。由于腙交换反应的热力学控制，在官能化过程中建立了纠错机制。这种可逆反应可以通过除去催化剂而方便地关闭，保留官能化。
The application of nanoparticles to the multivalent recognition of biomacromolecules or programmed self-assembly requires control over the relative placement of chemical groups on their surface. We have developed a method to direct the functionalization of surfaces of aldehyde-equipped gold nanoparticles using a DNA template. An error-correction mechanism is built into the functionalization process thanks to the thermodynamic control enabled by the hydrazone exchange reaction. This reversible reaction can be conveniently switched off by removing the catalyst, preserving the functionalization.