Positive effects of transcranial direct current stimulation in adult patients with attention-deficit/hyperactivity disorder - A pilot randomized controlled study
Positive effects of transcranial direct current stimulation in adult patients with attention-deficit/hyperactivity disorder - A pilot randomized controlled study
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DOI：
10.1016/j.psychres.2016.11.009
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发表时间：
2017-01-01
影响因子：
11.3
通讯作者：
Schestatsky, Pedro
中科院分区：
文献类型：
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作者：
Cachoeira, Carolina Tosetto;Leffa, Douglas Teixeira;Schestatsky, Pedro
近 30% 的注意力缺陷/多动障碍 (ADHD) 成年患者对标准药物干预措施没有反应或无法耐受。很少有临床研究探讨经颅直流电刺激（tDCS）（一种非侵入性神经调节技术）对该疾病的疗效和耐受性。我们对 17 名 ADHD 患者进行了一项双盲、假对照随机临床试验。 tDCS 的设置如下：2 mA/20 分钟/天，持续 5 天，阳极位于右背外侧前额皮质上方，阴极位于左背外侧前额皮质上方。在刺激后的四个不同时间点，通过成人 ADHD 自我报告量表（ASRS）测量 ADHD 症状，并通过希恩残疾量表（SDS）测量损伤。与假刺激组相比，主动 tDCS 后参与者的 ASRS 注意力不集中和 SDS 评分显着降低。此外，我们发现活跃 tDCS 组的 ASRS 总分有较低的趋势。后续数据分析显示，在 ASRS 注意力不集中、SDS 和 ASRS 总分方面，时间和治疗之间存在正向交互作用。成人 ADHD 患者短期应用 tDCS 改善了他们的症状，并且这种改善在刺激结束后持续存在。未来需要更大样本量的研究。
Almost 30% of adult patients with attention-deficit/hyperactivity disorder (ADHD) do not respond or tolerate standard pharmacological interventions. Few clinical investigations addressed the efficacy and tolerability of transcranial direct current stimulation (tDCS), a non-invasive neuromodulatory technique, in the disorder. We performed a double-blind, sham-controlled randomized clinical trial in 17 patients with ADHD. The set up for tDCS was the following: 2 mA/20 min/day for 5 days with the anode over the right dorsolateral prefrontal cortex and cathode over the left dorsolateral prefrontal cortex. ADHD symptoms were measured by the Adult ADHD Self-Report Scale (ASRS) and impairment with the Sheehan Disability Scale (SDS) in four different time points after stimulation. Participants achieved significant lower ASRS inattention and SDS scores after active tDCS in comparison with sham stimulation group. In addition, we detected a trend for a lower ASRS total score in the active tDCS group. Follow up data analysis revealed a positive interaction between time and treatment in both ASRS inattention, SDS and ASRS total scores. Short-term application of tDCS in adult patients with ADHD improved their symptoms, and this improvement persisted after the end of the stimulation. Future studies with larger sample sizes are needed.