Race-related Differences in Depression Onset and Recovery in Older Persons Over Time: The Health, Aging, and Body Composition Study
Race-related Differences in Depression Onset and Recovery in Older Persons Over Time: The Health, Aging, and Body Composition Study
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DOI：
10.1016/j.jagp.2013.09.001
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发表时间：
2014-07-01
影响因子：
7.2
通讯作者：
Simonsick, Eleanor M.
中科院分区：
文献类型：
--
作者：
Barry, Lisa C.;Thorpe, Roland J., Jr.;Simonsick, Eleanor M.
目的：评估老年人抑郁症发病和恢复的种族相关差异，总体和性别，并根据抑郁症检查死亡率的种族相关差异。设计：前瞻性队列研究。设置：一般社区在预先指定的邮政编码地区在孟菲斯，田纳西州和匹兹堡，宾夕法尼亚州。参与者：健康、衰老和身体成分研究中基线年龄为70-79岁的3，075人。测量值：在10年内的8个时间点使用10项流行病学中心抑郁量表评估抑郁症;患者被分类为非抑郁症（评分小于8）或抑郁症（评分为8或更高）。我们在每个18个月的时间间隔内创建了过渡变量，即从非抑郁或抑郁到非抑郁，抑郁或死亡，并确定了种族与这些过渡的平均可能性之间的关联。结果：几乎在所有时间点，黑人抑郁的比例都高于白人。调整人口统计学、常见慢性病和体重指数后，黑人比白人更有可能发生抑郁症（比值比[OR]：1.22; 95%置信区间[CI]：1.03-1.43）;在男性中，黑人比白人更有可能发生抑郁症（OR：1.44; 95% CI：1.24-2.89）。黑人也有更高的可能性从非抑郁症过渡到死亡（OR：1.79; 95% CI：1.30-2.46）。总的来说，在性别分层分析中，种族与抑郁症的恢复或从抑郁症到死亡的转变无关。结论：我们的研究结果强调了老年人抑郁症的种族差异，并鼓励进一步研究老年黑人患者的抑郁症病程。
Objectives: To evaluate race-related differences in depression onset and recovery in older persons, overall and by sex, and examine race-related differences in mortality according to depression. Design: Prospective cohort study. Setting: General community in pre-designated zip code areas in Memphis, Tennessee, and Pittsburgh, Pennsylvania. Participants: 3,075 persons aged 70-79 years at baseline in the Health, Aging, and Body Composition study. Measurements: Depression was assessed at eight time points over 10 years using the 10-item Center for Epidemiologic Studies-Depression scale; patients were categorized as nondepressed (score less than 8) or depressed (score of 8 or higher). We created variables for transitions across each 18-month time interval, namely, from nondepressed or depressed to nondepressed, depressed, or death, and determined the association between race and the average likelihood of these transitions over time. Results: A higher percentage of blacks than whites were depressed at nearly all time points. Adjusting for demographics, common chronic conditions, and body mass index, blacks had a higher likelihood of experiencing depression onset than whites (odds ratio [OR]: 1.22; 95% confidence interval [CI]: 1.03-1.43); among men, blacks were more likely to experience depression onset than whites (OR: 1.44; 95% CI: 1.24-2.89). Blacks also had a higher likelihood of transitioning from nondepressed to death (OR: 1.79; 95% CI: 1.30-2.46). Overall and in sex-stratified analyses, race was not associated with recovery from depression or with the transition from depression to death. Conclusion: Our findings highlight race differences in depression in older persons and encourage further research on the course of depression in older black patients.