INTRAMUSCULAR DEXMEDETOMIDINE, A NOVEL ALPHA2-ADRENOCEPTOR AGONIST, AS PREMEDICATION FOR MINOR GYNECOLOGICAL SURGERY
INTRAMUSCULAR DEXMEDETOMIDINE, A NOVEL ALPHA2-ADRENOCEPTOR AGONIST, AS PREMEDICATION FOR MINOR GYNECOLOGICAL SURGERY
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DOI：
10.1111/j.1399-6576.1991.tb03290.x
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发表时间：
1991-05-01
影响因子：
2.1
通讯作者：
SCHEININ, M
中科院分区：
文献类型：
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作者：
AANTAA, R;KANTO, J;SCHEININ, M
在一项双盲安慰剂对照研究中，研究了三种不同剂量（0.5、1.0和1.5 μ g/kg）的右旋美托咪啶（一种新型α-2-肾上腺素受体激动剂）对20名计划进行子宫扩张和刮宫（UD&C）的健康（阿萨身体状况I-II）女性的警惕性、麻醉需求、血流动力学和血浆儿茶酚胺水平的影响。 在硫喷妥钠麻醉诱导前60分钟肌肉注射药物。 N2 O/O2（70/30%）和硫喷妥钠用于维持。 在硫喷妥钠的需要量、血浆肾上腺素浓度、麻醉前和UD&C前镇静的主观或客观评估方面，两组之间没有显著差异。 右美托咪定给药后血压、心率和血浆去甲肾上腺素水平降低，3例患者因过度心动过缓（小于45次/min）接受阿托品治疗。 术后右美托咪定的血液动力学和镇静作用持续至观察期结束，即注射药物后4 h，表明肌内注射该术前用药药物可能导致与短期手术相关的药理作用持续时间长于最佳持续时间。
The effects of three different doses (0.5, 1.0 and 1.5-mu-g/kg) of dexmedetomidine, a novel alpha-2-adrenoceptor agonist, on vigilance, anaesthetic requirements, haemodynamics, and plasma catecholamine levels were investigated in a double-blind placebo-controlled study in 20 healthy (ASA physical status I-II) women scheduled for uterine dilatation and curettage (UD&C). The drug was administered intramuscularly 60 min before induction of anaesthesia with thiopentone. N2O/O2 (70/30%) and thiopentone was used for maintenance. There were no significant differences between the groups in thiopentone requirements, plasma adrenaline concentrations, or subjective or objective assessment of sedation before anaesthesia and UD&C. Blood pressure, heart rate, and plasma noradrenaline levels were reduced after dexmedetomidine, with three patients receiving atropine for excessive bradycardia (less than 45 beats min-1). The haemodynamic as well as the sedative effects of dexmedetomidine after surgery lasted until the end of the observation period, 4 h after the injection of the drug, indicating that intramuscular administration of this premedication agent may result in a longer than optimal duration of pharmacological actions in connection with short surgical procedures.