CONFORMATION AND DYNAMICS IN A Z-DNA TETRAMER
CONFORMATION AND DYNAMICS IN A Z-DNA TETRAMER
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DOI：
10.1016/0022-2836(81)90124-8
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发表时间：
1981-01-01
影响因子：
5.6
通讯作者：
DICKERSON, RE
中科院分区：
文献类型：
--
作者：
DREW, HR;DICKERSON, RE
据报道，左手Z-DNA有两种构象变化：Z到Z‘’转变，它涉及鸟嘌呤糖折叠从C-3‘’-endo到C-1‘-exo的变化，以及Zi到Zii的转变，对应于简单的3原子磷酸基团旋转。这两种运动都不会对碱基堆积或螺旋扭曲产生实质性影响，这是因为磷酸基团、糖分子和碱基对的独立运动程度在左旋Z螺旋中大于右旋B-DNA。对Z螺旋几何结构的详细考虑表明，Zi、Zii和Z“‘不是单独的物种，而只是对Z-DNA开放的所有构象的样本。
Two kinds of conformational variability have been reported for left-handed Z-DNA: the Z to Z'' transition, which involves a change in guanine sugar pucker from C-3''-endo to C-1''-exo, and the ZI to ZII transition, which corresponds to a simple 3-atom phosphate-group rotation. Neither of these motions substantially affects base stacking or helical twist and this is because the degree of independent motion of phosphate groups, sugar molecules and base-pairs is greater in the left-handed Z helix than in right-handed B-DNA. Detailed considerations of Z helix geometry suggest that ZI, ZII and Z'' are not separate species but only samplings of the full range of conformation open to Z-DNA.