Trends and advances in tumor immunology and lung cancer immunotherapy.
Trends and advances in tumor immunology and lung cancer immunotherapy.
复制标题
肿瘤免疫学和肺癌免疫治疗的趋势和进展。
DOI：
10.1186/s13046-016-0439-3
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发表时间：
2016-09-29
期刊：
影响因子：
--
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Aldarouish M;Wang C
在几种类型的肿瘤中，肺癌被认为是最致命的肿瘤之一，仍然是与癌症相关的死亡的主要原因。尽管与对症治疗相比，化疗药物可以提高生存率和生活质量，但癌症在化疗后通常仍会继续发展，而且往往会因严重的副作用而加重。在过去的几年里，人们对肺癌的免疫治疗越来越感兴趣，因为在获得有意义和持久的治疗反应方面取得了有希望的初步结果，毒性最小。本文分为两部分，第一部分讨论了人类免疫系统在控制和根除癌症中的作用以及肿瘤逃避免疫反应的机制。第二部分回顾了肺癌免疫治疗的最新进展，以及利用单抗评价治疗性疫苗的结果，特别是细胞毒性T淋巴细胞相关蛋白4，程序性死亡受体1途径。
Among several types of tumor, lung cancer is considered one of the most fatal and still the main cause of cancer-related deaths. Although chemotherapeutic agents can improve survival and quality of life compared with symptomatic treatment, cancers usually still progress after chemotherapy and are often aggravated by serious side effects. In the last few years there has been a growing interest in immunotherapy for lung cancer based on promising preliminary results in achieving meaningful and durable treatments responses with minimal manageable toxicity. This article is divided into two parts, the first part discusses the role of human immune system in controlling and eradicating cancer and the mechanisms of immune response evasion by tumor. The second part reviews the recent progress made in immunotherapy for lung cancer with results from trials evaluating therapeutic vaccines in addition to immune checkpoint blockade, specifically cytotoxic T lymphocyte associated protein 4, programmed death receptor 1 pathway, using monoclonal antibodies.
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DOI：
10.1084/jem.20090847
发表时间：
2009-12-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Francisco LM;Salinas VH;Brown KE;Vanguri VK;Freeman GJ;Kuchroo VK;Sharpe AH
通讯作者：
Sharpe AH
DOI：
10.1056/nejmoa1200694
发表时间：
2012-06-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer JR;Tykodi SS;Chow LQ;Hwu WJ;Topalian SL;Hwu P;Drake CG;Camacho LH;Kauh J;Odunsi K;Pitot HC;Hamid O;Bhatia S;Martins R;Eaton K;Chen S;Salay TM;Alaparthy S;Grosso JF;Korman AJ;Parker SM;Agrawal S;Goldberg SM;Pardoll DM;Gupta A;Wigginton JM
通讯作者：
Wigginton JM
影响因子：
4.4
作者：
Cretney, E;Takeda, K;Smyth, MJ
通讯作者：
Smyth, MJ
影响因子：
10.3
作者：
CLARK, WH;ELDER, DE;HALPERN, AC
通讯作者：
HALPERN, AC
影响因子：
168.9
作者：
Fehrenbacher, Louis;Spira, Alexander;Rittmeyer, Achim
通讯作者：
Rittmeyer, Achim