INFLUENCE OF NOVEL VERSUS HOME ENVIRONMENTS ON SENSITIZATION TO THE PSYCHOMOTOR STIMULANT EFFECTS OF COCAINE AND AMPHETAMINE
INFLUENCE OF NOVEL VERSUS HOME ENVIRONMENTS ON SENSITIZATION TO THE PSYCHOMOTOR STIMULANT EFFECTS OF COCAINE AND AMPHETAMINE
复制标题
DOI：
10.1016/0006-8993(95)00028-o
复制
发表时间：
1995-03-20
期刊：
影响因子：
2.9
通讯作者：
ROBINSON, TE
中科院分区：
文献类型：
--
作者：
BADIANI, A;BROWMAN, KE;ROBINSON, TE
急性精神反应（旋转行为的大鼠单侧6-OHDA病变），和敏化的发展，在大鼠接受连续7天注射安非他明（实验1）或可卡因（实验2）无论是在家里或在一个“新的”测试环境中进行了研究。家庭（HOME）和新型（NOVEL）笼在物理上相同，但一组大鼠在这些笼中生活并进行试验，而另一组大鼠在每次试验时从其生活的不锈钢吊笼转移到这些NOVEL试验笼中。在Expt. 1，NOVEL中对3.0 mg/kg苯丙胺i. p.的急性精神反应和致敏反应的发生（第一次和第七次测试之间的旋转反应增加）大于HOME环境。在Expt. 2，对20 mg/kg可卡因腹腔注射的急性反应没有显著的组间差异，但是在NOVEL环境中测试的动物比在HOME环境中测试的动物显示出更大的致敏性。此外，在NOVEL环境中用可卡因预处理的动物，而不是在HOME环境中用可卡因预处理的动物，显示出对注射生理盐水的条件性旋转行为。这些数据表明：（i）在NOVEL环境中，对安非他明和可卡因的精神兴奋作用的敏感性增强;（ii）这种现象似乎与NOVEL环境对这些药物的急性反应的影响无关;（iii）只有在NOVEL测试环境中给予可卡因治疗时，才会对上下文线索产生强烈的条件性精神兴奋反应。
The acute psychomotor response (rotational behavior in rats with a unilateral 6-OHDA lesion), and the development of sensitization, were studied in rats that received seven consecutive daily injections of amphetamine (Experiment 1) or cocaine (Experiment 2) either at home or in a 'novel' test environment. The home (HOME) and novel (NOVEL) cages were physically identical, but one group lived and was tested in these cages, whereas the rats in the other group were transported from the stainless steel hanging cages where they lived, to these NOVEL test cages, for each test session. In Expt. 1, the acute psychomotor response to 3.0 mg/kg of amphetamine i.p. and the development of sensitization (increase in the rotational response between the first and the seventh test session) were greater in the NOVEL than in the HOME environment. In Expt. 2, there were no significant group differences in the acute response to 20 mg/kg of cocaine i.p., but the animals tested in the NOVEL environment showed greater sensitization than animals tested in the HOME environment. In addition, the animals pretreated with cocaine in the NOVEL environment, but not those pretreated with cocaine in the HOME environment, showed conditioned rotational behavior in response to an injection of saline. These data indicate that: (i) sensitization to the psychomotor activating effects of both amphetamine and cocaine is enhanced in a NOVEL environment; (ii) this phenomenon appears to be independent of the effects of the NOVEL environment on the acute response to these drugs; (iii) a robust conditioned psychomotor response to contextual cues develops only when cocaine treatments are given in the NOVEL test environment.