BILHARZIASIS AND BLADDER CANCER
BILHARZIASIS AND BLADDER CANCER
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DOI：
10.1038/bjc.1965.33
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发表时间：
1965-01-01
影响因子：
8.8
通讯作者：
FRIPP, PJ
中科院分区：
文献类型：
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作者：
FRIPP, PJ
1964年9月在罗马举行的第一届国际寄生虫学大会上宣读的一篇论文，其中检查了作者关于血吸虫感染病例中尿[β]-葡萄糖醛酸酶排泄的发现。膀胱β-葡萄糖醛酸酶排泄增加与诱发的膀胱上皮肿瘤相关。它也与活动性膀胱血吸虫病有关。肠道血吸虫病或泌尿系感染明显消失的病例没有增加。血吸虫卵通过膀胱后对膀胱上皮细胞造成损伤，导致血吸虫水平升高。未检测到致癌物质。在乌干达的一些地区，已经发现了致癌的饮食因素，但这些与S。出血灶膀胱癌在某些地区是相对罕见的，而S。在其他地区，膀胱癌的发病率很高。结论是S.借由提供额外的[β]-葡萄糖醛酸酶至膀胱腔中以增加外源性致癌物葡萄糖醛酸苷（如果存在）的水解，嗜血杆菌感染仅可促使膀胱肿瘤的发作。
A paper read at the 1st International Congress of Para-sitology, Rome, September 1964, where the author''s findings on the excretion of urinary [beta]-glucuronidase in cases of bilharzial infestation are examined. Increased bladder [beta]-glucuronidase excretion is associated with induced bladder epithelial tumors. It is also associated with active bladder bilharziasis. No increases were found in cases of intestinal bilharziasis or cases which had apparently lost the urinary infection. The increase in levels was shown to be due to the damage caused to the bladder epithelium by the passage of Schistosoma hemato-bium eggs. No carcinogens could be detected. In areas of Uganda, carcinogenic dietary factors have been found but these do not coincide with S. hematobium foci. Bladder cancers are relatively rare in some areas where S. hematobium is endemic, while in other areas the incidence of bladder cancer is high. It is concluded that S. hematobium infestation could only precipitate the onset of a bladder tumor by providing extra [beta]-glucuronidase into the bladder lumen so as to increase the hydrolysis of exogenous carcinogen glucuronides if present.