Rare SP-A alleles and the SP-Al-6A4 allele associate with risk for lung carcinoma
Rare SP-A alleles and the SP-Al-6A4 allele associate with risk for lung carcinoma
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DOI：
10.1111/j.1399-0004.2005.00470.x
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发表时间：
2005-08-01
影响因子：
3.5
通讯作者：
Floros, J
中科院分区：
文献类型：
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作者：
Seifart, C;Lin, HM;Floros, J
除了吸烟，遗传因素可能会导致肺癌风险。肺表面活性物质成分可能介导对吸入致癌物质的反应和/或在肺功能和炎症中发挥作用。我们研究了表面活性蛋白（SP）遗传变异与肺癌风险之间的关系。对样本（n = 308）进行SP-A1、-A2、-B和-D标记等位基因基因分型。其中包括99例小细胞肺癌（SCLC，n = 31）或非SCLC（NSCLC，n = 68）患者，包括鳞状细胞癌（SCC，n = 35）和腺癌（AC）（n = 23）;对照组（n = 99），年龄、性别和吸烟状况（临床对照）与SCLC和NSCLC匹配;以及110例健康个体（人群对照）。我们发现（a）与SCLC无显著标志物关联，（B）与人群对照相比，罕见SP-A2（1A（9））和SP-A1（6A（11））等位基因与NSCLC风险相关，（c）与人群（6A（11））或临床对照（1A（9））相比，相同等位基因（1A（9），6A（11））与AC风险相关，和（d）与人群或临床对照相比，SP-A1-6A（4）等位基因（在大约10%的人群中发现）与SCC相关。SP-A变体与肺癌易感性之间似乎存在相关性，这表明SP-A等位基因可能是肺癌风险的有用标志物。
Next to cigarette smoking, genetic factors may contribute to lung cancer risk. Pulmonary surfactant components may mediate response to inhaled carcinogenic substances and/or play a role in lung function and inflammation. We studied associations between surfactant protein (SP) genetic variants and risk in lung cancer subgroups. Samples (n = 308) were genotyped for SP-A1, -A2, -B, and -D marker alleles. These included 99 patients with small cell lung carcinoma (SCLC, n = 31), or non-SCLC (NSCLC, n = 68) consisting of squamous cell carcinoma (SCC, n = 35), and adenocarcinoma (AC) (n = 23); controls (n = 99) matched by age, sex, and smoking status (clinical control) to SCLC and NSCLC; and 110 healthy individuals (population control). We found (a) no significant marker associations with SCLC, (b) rare SP-A2 (1A(9)) and SP-A1 (6A(11)) alleles associate with NSCLC risk when compared with population control, (c) the same alleles (1A(9), 6A(11)) associate with risk for AC when compared with population (6A(11)) or clinical control (1A(9)), and (d) the SP-A1-6A(4) allele (found in approximately 10% of the population) associates with SCC, when compared with population or clinical control. A correlation between SP-A variants and lung cancer susceptibility appears to exist, indicating that SP-A alleles may be useful markers of lung cancer risk.