RANDOMIZED CONTROLLED TRIAL OF ANTIBIOTICS IN PATIENTS WITH COUGH AND PURULENT SPUTUM
RANDOMIZED CONTROLLED TRIAL OF ANTIBIOTICS IN PATIENTS WITH COUGH AND PURULENT SPUTUM
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DOI：
10.1136/bmj.2.6035.556
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发表时间：
1976-01-01
影响因子：
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通讯作者：
WEST, RR
中科院分区：
文献类型：
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作者：
STOTT, NCH;WEST, RR
212名咳嗽和化脓性痰持续时间长达一周的成年人被随机分配到多西环素或安慰剂胶囊治疗长达10天。在治疗组和对照组中，咳嗽、化脓性痰、感觉“不舒服”和休息时间持续的时间相同，但在多西环素组持续流鼻涕的时间较短。在接下来的6个月里，两组下呼吸道感染、阴道感染、胃肠道不适和中耳炎的新发病例数量相同，但接受多西环素治疗的患者经历的新的上呼吸道感染较少。对于咳嗽和化痰的患者使用抗生素，医生们并没有达成共识，这些结果表明，其他有这些症状的健康人通常会在没有抗生素治疗的情况下好转。
Two hundred and twelve adults with cough and purulent sputum of up to one week's duration were allocated randomly to treatment with doxycycline or placebo capsules for up to 10 days. Cough, purulent sputum, feeling "off colour," and time off work lasted as long in treatment and control groups, but running nose persisted for a shorter time in the doxycycline group. The number of new episodes of lower respiratory tract infections, vaginal infections, gastrointestinal upsets, and otitis media over the next six months were the same in both groups, but fewer new upper respiratory infections were experienced by the doxycycline-treated patients. There is no consensus among doctors about using antibiotics in patients with cough and purulent sputum, and these results indicate that otherwise healthy people with these symptoms will usually get better without antibiotic treatment.