Asthma after consumption of snails in house-dust-mite-allergic patients: A case of IgE cross-reactivity
Asthma after consumption of snails in house-dust-mite-allergic patients: A case of IgE cross-reactivity
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DOI：
10.1111/j.1398-9995.1996.tb00147.x
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发表时间：
1996-06-01
期刊：
影响因子：
12.4
通讯作者：
Bonifazi, F
中科院分区：
文献类型：
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作者：
vanRee, R;Antonicelli, L;Bonifazi, F
一组来自意大利的28名患者进行了研究，他们在食用蜗牛后患有哮喘。所有患者还患有由屋尘螨引起的哮喘和/或鼻炎。RAST分析证实了对蜗牛和螨的联合致敏作用。在少数血清中，检测到与无脊椎动物来源的其他食物（贻贝和虾）反应的IgE抗体。RAST抑制试验表明，大多数抗钉螺IgE抗体与屋尘螨有交叉反应。而蜗牛对螨RAST的抑制作用不明显。提示屋尘螨是致敏物。免疫印迹分析显示，多个带蜗牛提取物识别IgE。与虾和螨之间的交叉反应性不同，原肌球蛋白在这些患者中作为交叉反应性过敏原仅起次要作用。这项研究的观察结果表明，蜗牛消费可能会导致严重的哮喘症状的室内尘螨过敏患者。因此，对螨过敏性哮喘患者进行蜗牛和其他无脊椎动物食物过敏的筛查可能是明智的。
A group of 28 patients from Italy was studied who had asthma after consumption of snail. All patients also had asthma and/or rhinitis caused by house-dust mite. RAST analyses confirmed the combined sensitization to snail and mite. In a few sera, IgE antibodies reactive with other foods of invertebrate origin (mussel and shrimp) were detected. RAST inhibition showed that most IgE antibodies against snail were cross-reactive with house-dust mite. In contrast, the mite RAST was not significantly inhibited by snail. This indicates that house-dust mite was the sensitizing agent. Immunoblot analyses revealed multiple bands in snail extract recognized by IgE. In contrast to what has been described for crossreactivity between shrimp and mite, tropomyosin played only a minor role as a cross-reactive allergen In these patients. The observations in this study indicate that snail consumption can cause severe asthmatic symptoms in house-dust-mite-allergic patients. It might, therefore, be advisable to screen mite-allergic asthma patients for allergy to snail and other invertebrate animal foods.