The adventitia: Essential role in pulmonary vascular remodeling.
The adventitia: Essential role in pulmonary vascular remodeling.
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DOI：
10.1002/cphy.c090017
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发表时间：
2011-01
影响因子：
5.8
通讯作者：
Frid M
中科院分区：
文献类型：
--
作者：
Stenmark KR;Nozik-Grayck E;Gerasimovskaya E;Anwar A;Li M;Riddle S;Frid M
一个迅速出现的概念是，血管外膜作为一个生物处理中心的检索，整合，存储和血管壁功能的关键调节剂的释放。它是血管壁最复杂的区室，包含多种细胞，包括成纤维细胞、免疫调节细胞、常驻祖细胞、血管内皮细胞和肾上腺素能神经。响应于血管应力或损伤，驻留的外膜细胞通常首先被激活和重编程，然后影响血管壁的张力和结构。实验数据表明，外膜成纤维细胞，外膜中最丰富的细胞成分，是血管壁功能的关键调节因子。响应于血管应激，例如过度扩张、缺氧或感染，外膜成纤维细胞被激活并经历表型变化，包括增殖、分化和细胞外基质蛋白和粘附分子的产生，活性氧类、趋化因子、细胞因子、生长因子和金属蛋白酶的释放，其共同地，直接影响中膜平滑肌细胞的张力和生长，并刺激循环炎性细胞和祖细胞向血管壁的募集和保留。常驻树突状细胞还参与“感知”血管应激，并与成纤维细胞和祖细胞积极沟通，以模拟涉及血管扩张的修复过程，血管扩张充当进一步递送炎症/祖细胞的管道。本文综述了目前的证据表明，外膜作为一个关键的调节器的肺血管壁的功能和结构，从“外”。
A rapidly emerging concept is that the vascular adventitia acts as a biological processing center for the retrieval, integration, storage, and release of key regulators of vessel wall function. It is the most complex compartment of the vessel wall and comprises a variety of cells including fibroblasts, immunomodulatory cells, resident progenitor cells, vasa vasorum endothelial cells, and adrenergic nerves. In response to vascular stress or injury, resident adventitial cells are often the first to be activated and reprogrammed to then influence tone and structure of the vessel wall. Experimental data indicate that the adventitial fibroblast, the most abundant cellular constituent of adventitia, is a critical regulator of vascular wall function. In response to vascular stresses such as overdistension, hypoxia, or infection, the adventitial fibroblast is activated and undergoes phenotypic changes that include proliferation, differentiation, and production of extracellular matrix proteins and adhesion molecules, release of reactive oxygen species, chemokines, cytokines, growth factors, and metalloproteinases that, collectively, affect medial smooth muscle cell tone and growth directly and that stimulate recruitment and retention of circulating inflammatory and progenitor cells to the vessel wall. Resident dendritic cells also participate in “sensing” vascular stress and actively communicate with fibroblasts and progenitor cells to simulate repair processes that involve expansion of the vasa vasorum, which acts as a conduit for further delivery of inflammatory/progenitor cells. This review presents the current evidence demonstrating that the adventitia acts as a key regulator of pulmonary vascular wall function and structure from the “outside in.”
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DOI：
10.1016/j.bbamcr.2008.10.004
发表时间：
2009-05
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Barker TH;Hagood JS
通讯作者：
Hagood JS
影响因子：
7.4
作者：
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通讯作者：
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DOI：
10.1152/ajplung.00417.2002
发表时间：
2003-08-01
影响因子：
4.9
作者：
Bogatkevich, GS;Tourkina, E;Ludwicka-Bradley, A
通讯作者：
Ludwicka-Bradley, A
影响因子：
8.3
作者：
Arribas, SM;Hillier, C;McGrath, JC
通讯作者：
McGrath, JC
影响因子：
6
作者：
Chambers, RC;Leoni, P;Heller, RA
通讯作者：
Heller, RA