ESTIMATION OF THE TIME-DEPENDENT ACCELERATED FAILURE TIME MODEL IN THE PRESENCE OF CONFOUNDING FACTORS

ESTIMATION OF THE TIME-DEPENDENT ACCELERATED FAILURE TIME MODEL IN THE PRESENCE OF CONFOUNDING FACTORS
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DOI:
10.1093/biomet/79.2.321
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发表时间:
1992-06-01
期刊:
影响因子:
2.7
通讯作者:
ROBINS, J
ROBINS, J
中科院分区:
数学2区
文献类型:
--
作者:
ROBINS, J

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考克斯和奥克斯(1984年,第66页)介绍了具有时间相关暴露的加速失效时间模型的“强版本”。我们提供的条件下,该模型可用于估计,从观察数据,时间变化的暴露或治疗的时间的因果关系的影响,在时间依赖性的混杂变量的存在下,感兴趣的事件。我们提出了一类模型参数的半参数检验和估计。这个类包含一个估计量,在Begun et al.(1983)的意义下是半参数有效的。
Cox & Oakes (1984, p. 66) introduced the 'strong version' of the accelerated failure time model with time-dependent exposures. We provide conditions under which this model could be used to estimate, from observational data, the causal effect of a time-varying exposure or treatment on time to an event of interest in the presence of time-dependent confounding variables. We propose a class of semiparametric tests and estimators for the model parameters. This class contains an estimator that is semiparametric efficient in the sense of Begun et al. (1983).