Mechanisms of metformin inhibiting cancer invasion and migration.
Mechanisms of metformin inhibiting cancer invasion and migration.
复制标题
DOI：
--
复制
发表时间：
2020-09
影响因子：
2.2
通讯作者：
Yong Chen;He Li;Jing Wang
中科院分区：
文献类型：
--
作者：
Yong Chen;He Li;Jing Wang
癌症目前是全球死亡的主要原因之一。癌症的侵袭和转移使局部生长的癌症转变为一种全身性和危及生命的疾病，这是癌症治疗的最大挑战。最近的研究表明，二甲双胍是治疗2型糖尿病（T2DM）最常用的一线口服药物，可以预防和治疗多种癌症。此外，多项证据表明，二甲双胍可以抑制肿瘤的侵袭和转移，从而改善肿瘤患者的预后。为了更好地了解二甲双胍的抗癌作用，本文综述了二甲双胍抑制肿瘤侵袭转移的潜在机制，包括AMPK信号通路、EMT信号通路、表观遗传修饰等。然而，仍有许多问题有待解决，需要更多的临床试验来证明二甲双胍对肿瘤侵袭转移的抑制作用。
Cancer currently ranks among the leading causes of death globally. Cancer invasion and metastasis transform locally grown cancers to a systemic and life-threatening disease, which accounts for the most significant challenge in cancer treatment. Recent studies showed that Metformin, the most commonly used first-line oral drug for the treatment of type 2 diabetes (T2DM), could prevent and treat various cancers. Moreover, multiple evidence suggested that metformin inhibited cancer invasion and metastasis, which could improve the prognosis of cancer patients administrated with metformin. To better understand the anti-cancer role of metformin, the present review summarized the potential mechanisms of inhibiting cancer invasion and metastasis by metformin, including AMPK signaling pathway, EMT signaling pathway, epigenetic modification and so on. However, multiple problems remain unresolved and more clinical trials are needed to prove the inhibition of cancer invasion and metastasis by metformin.