The impact of ageing on right ventricular longitudinal function in healthy subjects: a pulsed tissue Doppler study
The impact of ageing on right ventricular longitudinal function in healthy subjects: a pulsed tissue Doppler study
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DOI：
10.1093/ejechocard/jen313
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发表时间：
2009-06-01
影响因子：
--
通讯作者：
Galderisi, Maurizio
中科院分区：
文献类型：
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作者：
Innelli, Pasquale;Esposito, Roberta;Galderisi, Maurizio
为探讨年龄对脉冲组织多普勒测量正常人右室三尖瓣环的影响，并提出不同年龄段的参考值，对298例正常人（男/女= 186/112）进行了心尖四腔切面多普勒超声心动图和脉冲组织多普勒三尖瓣环测量。测量三尖瓣环平面收缩期位移（TAPSE）、右房流出道多普勒指数、三尖瓣流入道多普勒指数、右房内径、下腔静脉内径及血流动力学参数。还记录了三尖瓣环的脉冲组织多普勒外侧角，并测定了环收缩期（Sa）、舒张早期（Ea）和心房（Aa）峰值速度和Ea/Aa比值。计算三尖瓣E峰速度与Ea的比值（E/Ea比值）作为右房压力的指标。人口分为七个年龄段：10-19岁，20-29岁，30-39岁，40-49岁，50-59岁，60-69岁和> 70岁。TAPSE、Sa、Ea、Ea/Aa比值随年龄增加而逐渐降低，Aa、E/Ea比值随年龄增加而升高（均P < 0.0001）。E/Ea比值在11-20岁年龄段为4.1 +/- 0.9，在> 70岁的受试者中为5.4 +/- 1.5（P < 0.0001）。通过多元线性回归分析，调整心率和体重指数后，年龄是平均Sa，Ea和Aa速度和E/Ea ratio. Aging的主要独立预测因素，显示了对脉冲组织多普勒衍生的指标RV心肌功能在健康受试者的独立影响。我们的数据提供了参考价值的脉冲组织多普勒的右心室几十年。
To evaluate the influence of age on pulsed Tissue Doppler-derived measurements of right ventricular (RV) tricuspid annulus in a population of healthy subjects and to propose reference values according to age decades.Two hundred and ninety-eight healthy subjects (M/F = 186/112) underwent Doppler echocardiography and pulsed Tissue Doppler of tricuspid annulus in apical four-chamber view. Tricuspid annular plane systolic excursion (TAPSE), Doppler indexes of RV outflow tract and of tricuspid inflow, right atrial dimension and inferior vena cava size, and collapsibility were measured. Pulsed Tissue Doppler lateral corner of the tricuspid annulus was also recorded and annular systolic (Sa), early diastolic (Ea), and atrial (Aa) peak velocities and Ea/Aa ratio determined. The ratio of tricuspid E peak velocity and Ea (E/Ea ratio) was calculated as an index of right atrial pressure. The population was divided in seven age decades: 10-19, 20-29, 30-39, 40-49, 50-59, 60-69, and > 70 years. TAPSE, Sa, Ea, and Ea/Aa ratio were progressively reduced and both Aa and E/Ea ratio increased with the increasing age groups (all P < 0.0001). E/Ea ratio was 4.1 +/- 0.9 in the age decade 11-20 years and 5.4 +/- 1.5 in subjects > 70 years (P < 0.0001). By multi-linear regression analyses, after adjusting for heart rate and body mass index, age was the main independent predictor of average Sa, Ea, and Aa velocities and of E/Ea ratio.Ageing shows an independent impact on pulsed Tissue Doppler-derived indexes of RV myocardial function in healthy subjects. Our data provide reference values of pulsed Tissue Doppler of the right ventricle for age decades.