THE ARGOS GENE ENCODES A DIFFUSIBLE FACTOR THAT REGULATES CELL FATE DECISIONS IN THE DROSOPHILA EYE
THE ARGOS GENE ENCODES A DIFFUSIBLE FACTOR THAT REGULATES CELL FATE DECISIONS IN THE DROSOPHILA EYE
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DOI：
10.1016/0092-8674(92)90615-j
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发表时间：
1992-06-12
期刊：
影响因子：
64.5
通讯作者：
RUBIN, GM
中科院分区：
文献类型：
--
作者：
FREEMAN, M;KLAMBT, C;RUBIN, GM
argos基因编码一种蛋白质，这种蛋白质是生存所必需的，并且调节果蝇眼睛中细胞的决定。argos突变眼的发育分析表明，通常是非神经元的神秘细胞转化为额外的光感受器，并且额外的视锥细胞和色素细胞也被招募。克隆分析表明，argos的行为非自主的，可以在几个细胞直径的范围内扩散。argos基因的概念翻译表明它编码一种分泌蛋白。
The argos gene encodes a protein that is required for viability and that regulates the determination of cells in the Drosophila eye. A developmental analysis of argos mutant eyes indicates that the mystery cells, which are usually nonneuronal, are transformed into extra photoreceptors, and that supernumerary cone cells and pigment cells are also recruited. Clonal analysis indicates that argos acts nonautonomously and can diffuse over the range of several cell diameters. Conceptual translation of the argos gene suggests that it encodes a secreted protein.