Detailed study of Tröger's base separation by SMB process
Detailed study of Tröger's base separation by SMB process
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SMB 工艺对 Tröger 碱基分离的详细研究
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
G. Guiochon
中科院分区：
文献类型：
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作者：
K. Mihlbachler;A. Seidel;G. Guiochon
该研究表明：(1)为了确定最佳操作条件，对分离过程进行适当的建模是非常重要的；(2)需要对进料组分的吸附等温线进行准确的建模。用多层吸附等温线模型成功地描述了Troger碱在ChiralPak AD固定相上的吸附过程。由于这些模型的复杂性，平衡理论不能用代数方法确定合适的操作参数范围。作为另一种选择，使用平衡-色散模型和可靠的数值算法来扫描大范围的操作区域，并确定该分离区域。为了验证这些计算的结果，还通过对选定工作点的产品纯度和产率的测量来实验检测分离区域。紫外光检测器和旋光仪的结合使得能够准确地监测两种对映体的内部浓度分布。将这些曲线与多层吸附等温线模型计算的曲线进行了比较。此外，还研究了塔组的非均质性对SMB工艺性能的影响。即使在强非线性条件下，计算值与实验值之间也有很好的一致性。美国化学工程师学会学报，50：611-624,2004
This investigation of the separation of Troger's base by the SMB process demonstrates: (1) the major importance of a proper modeling of the separation in order to determine the optimal operating conditions; (2) the need of an accurate modeling of the adsorption isotherms of the feed components. The adsorption of Troger's base onto the stationary phase ChiralPak AD was successfully described by multilayer adsorption isotherm models. Due to the complexity of these models, the region of suitable operating parameters cannot be determined algebraically by the equilibrium theory. As an alternative, the equilibrium-dispersive model, and a reliable numerical algorithm were used to scan a wide operating region, and to define this separation area. To verify the results of these calculations, the separation area was also experimentally detected by performing measurements of product purity and production rate for selected operating points. The combination of a UV detector and a polarimeter allows the accurate monitoring of the internal concentration profiles of both enantiomers. These profiles were compared to the profiles calculated using the multilayer adsorption isotherm models. In addition, the influence of the heterogeneity of the column set on the performance of the SMB process, is studied. Even under strongly nonlinear conditions, excellent agreements between calculated and experimental profiles were obtained. © 2004 American Institute of Chemical Engineers AIChE J, 50: 611–624, 2004