Breath carbon monoxide as an indication of smoking habit
Breath carbon monoxide as an indication of smoking habit
复制标题
DOI：
10.1378/chest.117.3.758
复制
发表时间：
2000-03-01
期刊：
影响因子：
9.6
通讯作者：
Morice, AH
中科院分区：
文献类型：
--
作者：
Middleton, ET;Morice, AH
设计：为了给吸烟者和非吸烟者提供一个正常范围，41名门诊患者和24名健康受试者被问及他们的吸烟习惯，并被要求对CO监测仪(EC50 Smokerlyser；Bedfont Instruments；在随后的一项单盲研究中，51名不同的门诊患者没有被告知研究的目的，并通过广泛的问卷调查、肺活量测定和Smokerlyser估计进行了评估。地点：英国谢菲尔德北方综合医院的胸部诊所和肺部内科。参与者：第一阶段包括41名到胸部诊所就诊的门诊患者和24名非门诊同事，在第二阶段，另外51名不同的门诊患者：被研究。测量和结果：吸烟者的平均(SD)呼吸CO水平为17.4(11.6)ppm，不吸烟者的平均呼吸CO水平为1.8(1.3)ppm(p<；0.001)。以6ppm为临界值，对门诊患者的选择性为96%，灵敏度为94%。在51名研究患者中，有5人在接受调查的问卷中承认吸烟。8人否认吸烟，但平均呼吸CO>；6ppm(7.5至42ppm)。其中，3人在被解释读数的含义后承认吸烟。结论：呼气CO浓度提供了一种简单、非侵入性和即时评估患者吸烟状况的方法。6ppm的读数强烈表明门诊病人是吸烟者。
Study objective: To assess whether the breath carbon monoxide (CO) concentration can be used to determine a patient's smoking habits in a respiratory outpatient clinic.Design: To provide a normal range for smokers and nonsmokers, 41 outpatients and 24 Healthy subjects were questioned on their smoking habits and asked to provide two breaths into a CO monitor (EC50 Smokerlyser; Bedfont Instruments; Kent, UK), In a subsequent single-blind study, 51 different outpatients were not told of the purpose of the study and were assessed by extensive questionnaire, spirometry, and Smokerlyser estimation.Setting: The Chest Clinic and Pulmonary Medicine Department at the Northern General Hospital, Sheffield, UK.Participants: Phase 1 involved 41 outpatients attending the Chest Clinic and 24 nonoutpatient colleagues, In phase 2, an additional 51 different outpatients: were studied.Measurements and results: The mean (SD) breath CO levels were 17.4 (11.6) parts per million (ppm) for smokers and 1.8 (1.3) ppm for nonsmokers (p < 0.001). A level of 6 ppm was taken as the cutoff, as this gave a selectivity of 96% and a sensitivity of 94% for outpatients. Of the 51 study patients, 5 admitted to smoking in the administered questionnaire. Eight denied smoking but had a mean breath CO > 6 ppm (7.5 to 42 ppm). Of these, three admitted to smoking after being explained the implication of the reading.Conclusions: Breath CO concentration provides an easy, noninvasive, and immediate way of assessing a patient's smoking status. A reading > 6 ppm strongly suggests that an outpatient is a smoker.