Dietary patterns and colorectal cancer in a Japanese population: The Fukuoka Colorectal Cancer Study
Dietary patterns and colorectal cancer in a Japanese population: The Fukuoka Colorectal Cancer Study
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DOI：
10.1017/s0007114510002606
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发表时间：
2010-12-01
影响因子：
3.6
通讯作者：
Terasaka, Reiji
中科院分区：
文献类型：
--
作者：
Kurotani, Kayo;Budhathoki, Sanjeev;Terasaka, Reiji
在日本，很少有研究探讨饮食模式与结直肠癌之间的关系。我们在一项基于社区的病例对照研究中调查了与结直肠癌风险相关的饮食模式。还检查了结直肠癌不同部位与饮食模式的关联。数据来自福冈结直肠癌研究，包括2000年9月至2003年12月采访的800例病例和775名对照。这些病例在此期间入住其中一家参与医院进行首次手术治疗。我们通过对二十九种食物组和特定食物的摄入量进行主成分分析来确定饮食模式。使用每种饮食模式的四分位数类别，并在分析中调整非饮食生活方式因素和总能量摄入量。我们确定了三种饮食模式：谨慎、高脂肪和清淡饮食模式。以大量摄入蔬菜、水果、海鲜和大豆食品为特征的审慎饮食模式与结直肠癌的总体风险呈现近乎显着的保护性相关性（趋势P=0.054），并且与远端结肠癌的风险降低具有统计学显着相关性（趋势P=0.002），但与近端结肠癌或直肠癌的风险降低无关。高脂肪和清淡饮食的饮食模式与结直肠癌的总体或特定部位风险没有显着相关。总之，在日本进行的一项相当大的病例对照研究中，谨慎的饮食模式与结直肠癌风险降低相关，尤其是远端结肠癌风险降低。
Few studies have addressed the relation between dietary patterns and colorectal cancer in Japan. We investigated dietary patterns in relation to colorectal cancer risk in a community-based case-control study. The association with dietary patterns was also examined for different sites of colorectal cancer. Data were derived from the Fukuoka Colorectal Cancer Study, including 800 cases and 775 controls interviewed from September 2000 to December 2003. The cases were admitted to one of the participating hospitals for the first surgical treatment during this period. We identified dietary patterns using principal component analysis of intakes of twenty-nine items of food groups and specific foods. Quartile categories of each dietary pattern were used, and non-dietary lifestyle factors and total energy intake were adjusted for in the analysis. We identified three dietary patterns: prudent, high-fat and light-meal patterns. The prudent dietary pattern characterised by high intakes of vegetables, fruits, seafoods and soya foods showed a nearly significant protective association with the overall risk of colorectal cancer (trend P=0.054), and it was statistically significantly related to a decreased risk of distal colon cancer (trend P=0.002), but not to that of either proximal colon or rectal cancer. The high-fat and light-meal dietary patterns were not materially related to the overall or site-specific risk of colorectal cancer. In summary, a prudent dietary pattern was associated with a decreased risk of colorectal cancer, especially with that of distal colon cancer, in a fairly large case-control study in Japan.