Anti-inflammatory activity of Indian black tea (Sikkim variety)
Anti-inflammatory activity of Indian black tea (Sikkim variety)
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DOI：
10.1016/j.phrs.2004.07.008
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发表时间：
2005-02-01
影响因子：
9.3
通讯作者：
Sen, T
中科院分区：
文献类型：
--
作者：
Chaudhuri, AKN;Karmakar, S;Sen, T
本研究结合一定的标准药物，对红茶（Camellia sinensis， Sikkim品种）热水提取物的抗炎（参考炎症的主要体征）及其他相关药理活性进行了评价。提取物对卡拉胶素、组胺、血清素和前列腺素引起的足底炎症有显著的抑制作用。提取物抑制渗出性炎症。茶提取物还能抑制棉花颗粒诱导的肉芽肿形成和佐剂诱导的多发性关节炎。红茶提取物对葡萄糖氧化酶介导的炎症有明显的抑制作用。目前的观察证实了这种红茶的功效，无论是在渗出和增殖形式，还是在炎症的慢性阶段。(C) 2004 Elsevier Ltd.版权所有。
In this study, the anti-inflammatory (in reference to the cardinal signs of inflammation) and other related pharmacological activities of the hot water extract of black tea (Camellia sinensis, Sikkim variety) were evaluated along with certain standard drugs. The extract showed significant inhibitory activity against carrageenin, histamine, serotonin and prostaglandin-induced pedal inflammation. The extract inhibited exudative inflammation. The tea extract also inhibited cotton pellet-induced granuloma formation and adjuvant-induced polyarthritis. Black tea extract showed significant inhibition against glucose oxidase-mediated inflammation. The present observations establish the efficacy of this particular variety of black tea, both in the exudative and proliferative forms and as well in the chronic phase of inflammation. (C) 2004 Elsevier Ltd. All rights reserved.